This research aims to evaluate the effectiveness of a dietary supplement on reducing inflammation and improving muscle health. The product is a food supplement notified to the Ministry of Health consisting of: hydroxymethylbutyrate, carnosine, lactoferrin and magnesium, which help reduce inflammation and intestinal permeability and to improve muscle health.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
60
1 sachet per day for 4 months
1 sachet per day for 4 months
l'Istituto di Riabilitazione e cura "Santa Margherita" di Pavia, Azienda di Servizi alla Persona (ASP).
Pavia, Italy
RECRUITINGInflammation status
A blood sample will be collected and analised for C-reactive protein and tumor necrosis factor alfa (TNF alfa)
Time frame: At the beginning of the treatment
Inflammation status
A blood sample will be collected and analised for C-reactive protein and tumor necrosis factor alfa (TNF alfa)
Time frame: After 4 months of treatment
Muscle strength evaluation
Muscle strength was measured by handgrip strength according to standard procedures by a hydraulic hand dynamometer (Jamar 5030 J1, Sammons Preston Rolyan, Bolingbrook, Canada with an accuracy of 0.6 N). The subject holds the dy-namometer in the hand to be tested, with the arm at right angles and the elbow by the side of the body, applying an isometric contraction
Time frame: At the beginning of the treatment
Muscle strength evaluation
Muscle strength was measured by handgrip strength according to standard procedures by a hydraulic hand dynamometer (Jamar 5030 J1, Sammons Preston Rolyan, Bolingbrook, Canada with an accuracy of 0.6 N). The subject holds the dy-namometer in the hand to be tested, with the arm at right angles and the elbow by the side of the body, applying an isometric contraction
Time frame: After 4 months of treatment
body composition assessment
Body composition represented by fat free mass and fat mass were measured using a Lunar Prodigy DXA (GE Medical Systems, WI, USA).
Time frame: At the beginning of the treatment
body composition assessment
Body composition represented by fat free mass and fat mass were measured using a Lunar Prodigy DXA (GE Medical Systems, WI, USA).
Time frame: After 4 months of treatment
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Physical performance assessment
Physical performance was assessed using the Short Physical Performance battery test (SPPB) which comprised of gait speed, chair-stand test, and balance (three different tests that assess the ability to stand with the feet together in the side-by-side, semi-tandem, and tandem positions); each component was scored from 0 (not possible) to 4 (best performance) and the scores were added up to a total score ranging from 0 to 12.
Time frame: At the beginning of the treatment
Physical performance assessment
Physical performance was assessed using the Short Physical Performance battery test (SPPB) which comprised of gait speed, chair-stand test, and balance (three different tests that assess the ability to stand with the feet together in the side-by-side, semi-tandem, and tandem positions); each component was scored from 0 (not possible) to 4 (best performance) and the scores were added up to a total score ranging from 0 to 12.
Time frame: After 4 months of treatment
Gut permeability.
A blood sample will be collected and analised for indican
Time frame: At the beginning of the treatment
Gut permeability.
A blood sample will be collected and analised for indican
Time frame: After 4 months of treatment