A prior research indicated that asynchrony between the patient and ventilator occurred in 33 percent of 19,175 breaths, and was seen in every patient. The most prevalent kind of asynchrony was ineffective triggering (68%), followed by delayed termination (19%), double triggering (4%) and premature termination (3%). Asynchrony between the patient and ventilator increased considerably with decreasing levels of peak inspiratory pressure, positive end-expiratory pressure, and set frequency.Despite this, more asynchrony categories exist, and there is no widely accepted categorization. Major asynchronies, however, include auto trigger, ineffective effort, and double trigger, while minor asynchronies include early/late cycle, trigger delay, and spontaneous breaths during a mandatory breath. This study aims to compare the safety and efficacy of a closed-loop synchronization controller with conventional control of synchronization during invasive mechanical ventilation of spontaneous breathing of pediatric patients in a pediatric intensive care unit (PICU).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
15
One-hour period where the pressure support of spontaneous breath will be automatically titrated based on pressure and flow waveform analysis obtained from the patient.
One-hour period where the pressure support of spontaneous breath will be manually set.
Aydin Obstetric and pediatrics Hospital
Aydin, Turkey (Türkiye)
RECRUITINGErzurum Regional Research and Training Hospital
Erzurum, Turkey (Türkiye)
RECRUITINGErzurum Regional Research and Training Hospital
Erzurum, Turkey (Türkiye)
RECRUITINGCam Sakura Research and Training Hospital
Istanbul, Turkey (Türkiye)
RECRUITINGThe Health Sciences University Izmir Behçet Uz Child Health and Diseases Research and Training Hospital
Izmir, Turkey (Türkiye)
RECRUITINGAsynchrony Index
\[(major asynchronies+minor asynchronies )/(total number of breaths + ineffective efforts)\]x100
Time frame: 1 hour
Major asynchronies
\[(major asynchronies)/(total number of breaths + ineffective efforts)\]x100
Time frame: 1 hour
Minor asynchronies
\[(minor asynchronies)/(total number of breaths + ineffective efforts)\]x100
Time frame: 1 hour
Comfort Behavioral Score
The Comfort Behavioral Scale yields points based on scores obtained from the Comfort B Scale. Scores below 10 indicate that the patient may be over-sedated, while scores between 12 and 17 suggest that the patient is adequately comfortable. Scores above 17 may suggest that the patient is experiencing inadequate sedation
Time frame: 1 hour
Leak
Percentage of leak around endotrachel tube (%)
Time frame: 1 hour
Mean SpO2
Mean peripheral oxygen saturation (%)
Time frame: 1 hour
Mean EtCO2
Mean end-tidal carbon dioxide (mm Hg)
Time frame: 1 hour
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