UVB-Induced MVP Release in Human Skin

Wright State University8 enrolled

Overview

This study is designed to assess if ultraviolet B radiation (UVB) found in sunlight causes the release of microvesicle particles in human skin, and if antioxidant vitamins can block their production.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Ultraviolet B Radiation Microvesicle Particles

Interventions

Vitamin CDIETARY_SUPPLEMENT

Two Vitamin C tablets daily for 8 days.

Vitamin EDIETARY_SUPPLEMENT

One Vitamin E tablet daily for 8 days.

Eligibility

Sex: MALEMin age: 21 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Male subjects * Ages 21 to 45 * Skin type: Fitzpatrick Type I or II Exclusion Criteria: * Have underlying diseases that could affect wound healing * On medications that are known photosensitizers (e.g., doxycycline) or anti-inflammatories (e.g., NSAIDS \[except for low-dose aspirin\] or steroids) * History of abnormal scarring (e.g., keloids) * Should not be on Vitamin C or E supplements for past month * Unable to understand/complete informed consent * Large volar arm tattoos that would inhibit the ability to conduct/evaluate the skin testing * Renal compromise/kidney stones or allergy to Vitamin C/Vitamin E or lidocaine anaesthetic * Use of tanning bends or recent UVB exposure to the areas in the past 3 months * Recent (within 1 week) use to sunscreen to volar forearms

Locations (1)

Wright State Physicians

Fairborn, Ohio, United States

Outcomes

Primary Outcomes

Change in microvesicle particles (MVP) levels from baseline

Levels of microvesicle particles will be determined from skin biopsies

Time frame: Day 8

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.