Prognosis of small vessel disease (SVD) depends on the underlying type of SVD and index manifestation. The aim of this prospective, observational cohort study is to determine the risk of different outcome events among patients with SVD according to the type of index presentation.
Study Type
OBSERVATIONAL
Enrollment
900
Department of Neurology, Inselspital Bern University Hospital
Bern, Switzerland
RECRUITINGIntracerebral haemorrhage (ICH)
Non-traumatic, intracerebral haemorrhage (ICH, including convexity subarachnoid haemorrhage)
Time frame: 1 year
Ischaemic stroke
Defined by CT and/or MRI
Time frame: 1 year
Cardio-vascular death
According to the treating physician
Time frame: 1 year
Other intracranial bleeding
Subdural haematoma, subarachnoid haemorrhage
Time frame: 1 year
Other (transient) neurological attacks
Including transient ischaemic attack (TIA), transient neurological attack (TNA), amyloid spells, (focal) seizures
Time frame: 1 year
Cognitive impairment
Montreal Cognitive Assessment (MoCA, range 0-30 points) \< 26 points (corresponding to impaired cognitive function) and/or new impairment in activities of daily living as defined by the treating physician.
Time frame: 1 year
New-onset of extracranial vascular disease
As judged by the treating physician
Time frame: 1 year
Functional outcome
Modified Rankin scale score (ordinal score, range 0-6, a score of 0 corresponds to no symptoms at all, while a score of 6 corresponds to death)
Time frame: 1 year
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