Effects of BFR Interventions in Healthy Individuals and Individuals With COPD

Morten Hostrup, PhD105 enrolled

Overview

The purpose of the study is to investigate the effect of different blood flow restriction (BFR) interventions on muscle function and adaptations both in healthy well-trained individuals and individuals diagnosed with COPD.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

TRIPLE

Enrollment

105

Conditions

Healthy COPD

Interventions

BFR during trainingOTHER

Healthy participants and participants diagnosed with COPD will be randomized to either the BFR-ST and BFR-HIT or to HL-ST and HIT

BFR during restOTHER

Participants experiencing acute exacerbation of their COPD requiring hospitalization will be randomized to either BFR-P, BFR-NMES or the control group throughout their hospitalization.

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion criteria for participants with COPD group are: * Diagnosis with COPD Exclusion criteria participants in the COPD group are * Having experienced an acute exacerbation of COPD within the last 6 weeks (Study A) * Taking part in pulmonary rehabilitation within the last 3 months (Study A) * Presenting with a history of thromboembolic event in the lower limbs. Inclusion criteria for healthy participants are: * Age between 18 and 40 years. * Maximal oxygen uptake (VO2max) of \>55 ml O2/kg/min for men and \>50 ml O2/kg/min for women * BMI of \<26 and normal ECG and blood pressure. Exclusion criteria for healthy participants are: * Smoking * chronic disease, * Use of prescription medication * Pain due to current or previous musculoskeletal injury * Resistance training more than once per week in the 12 months leading up to the intervention.

Locations (1)

August Krogh Building

Copenhagen, Denmark

RECRUITING

Outcomes

Primary Outcomes

Muscle strength

Maximal voluntary isometric contraction of m. quadriceps femoris

Time frame: Change assessed from before to after the intervention (6 weeks in study A, on average 7 days in study B)

Secondary Outcomes

Lean mass

Lean mass assessed by dual X-ray absorptiometry (DXA)

Time frame: Change assessed from before to after the 6 week intervention

Maximal oxygen consumption

VO2max during incremental exercise

Time frame: Change assessed from before to after the 6 week intervention

Skeletal muscle mitochondrial respiration

High resolution respirometry

Time frame: Change assessed from before to after the intervention (6 weeks in study A, on average 7 days in study B)

Fiber cross-sectional area

Immunohistochemistry to determine fiber cross-sectional area

Time frame: Change assessed from before to after the intervention (6 weeks in study A, on average 7 days in study B)

Myonuclei

Immunohistochemistry to determine number of myonuclei

Time frame: Change assessed from before to after the intervention (6 weeks in study A, on average 7 days in study B)

Functional exercise capacity

Number of repetitions achieved during a 1-minute sit-to-stand test

Time frame: Change assessed from before to after the 6 week intervention (only in individuals with COPD)

Central Contacts

Morten Hostrup

CONTACT

+4535321595 mhostrup@nexs.ku.dk

Data from ClinicalTrials.gov

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