Establishment of a Method for Extraction and Quantification of Gingival Tissue Nicotine y

University of Liege20 enrolled

Overview

establishment of a method for extraction and quantification of gingival tissue nicotine in relation to conventional tobacco biomarkers: a pilot study

The study aim to establish a method for extraction and quantification of gingival tissue nicotine. Additionnaly, the relationship between the nicotine tissue intoxication with others smoking indicators will be evaluated as mentionned in the following PICO question: * P: Smoker patients * I: Biopsie of gingival tissue * C: Non-smoker patient * O: nicotine dependence test (FTND), salivary cotinine, fibroblast nicotine, number of cigarette consumed per day (NCC) and the pack-year (PY)

Study Type

OBSERVATIONAL

Enrollment

Conditions

Smoking, Cigarette

Interventions

biopsieDIAGNOSTIC_TEST

gingival biopsie

Eligibility

Sex: ALLMin age: 18 YearsMax age: 99 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * non smokers * smokers Exclusion Criteria: * not able to have biopsie

Locations (1)

Salhi

Liège, Liege, Belgium

RECRUITING

Outcomes

Primary Outcomes

nicotine

nicotine in gingival fibroblast

Time frame: baseline

nicotine dependance

Fagerström test for nicotine dependence

Time frame: baseline

Secondary Outcomes

salivary cotinine

Time frame: baseline

number of cigarette consumed

Time frame: baseline

pack-year

Time frame: baseline

Central Contacts

Leila Salhi, PhD

CONTACT

003243233123 l.salhi@chuliege.be

Data from ClinicalTrials.gov

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