Study Evaluating the Safety and Tolerability of RCT1100 in Healthy and PCD Subjects

Major Inclusion Criteria: * Healthy, adult, male or female of, 18-75 years of age, inclusive, at screening. * Participant has disease causing mutations in the DNAI1 gene * The participant has a forced expiratory volume in one second (FEV1) of at least 50% predicted. Major Exclusion Criteria: * History or presence of clinically significant medical, surgical, clinical laboratory, or psychiatric condition or disease. * History of cancer, with exception of adequately treated basal cell or squamous cell carcinoma of the skin. * Medically significant hemoptysis * Anticoagulation therapy for the treatment of a pulmonary embolus or has had a pulmonary embolus in the last 6 months of screening. * Active tuberculosis infection. * Laboratory abnormalities in clinical laboratory tests at screening: 1. Serum creatinine level 2. Total bilirubin, aspartate aminotransferase or alanine aminotransferase values 3. Hematological or coagulation values outside the normal reference range * Any medical history of disease that has the potential to cause a rise in total bilirubin over the ULN * History of alcohol abuse or drug addiction with the last year of screening. * Active smoker (vaping included). Other protocol defined inclusion/exclusion criteria may apply.