Effects of IAP-EOGBSD on Maternal Vaginal Microbiome, Offspring's Gut Microbiome and Metabolites.

Zhujiang Hospital492 enrolled

Overview

In view of the current status of prevention and research on GBS disease in mothers and infants at home and abroad, this project intends to explore the characteristics of vaginal microbiota of GBS-colonized pregnant women in southern China, the impact of IAP prevention of GBS-EOD on vaginal flora, and the effect of IAP prevention of GBS-EOD on intestinal flora and immune production in offspring, so as to improve the ability to prevent and treat GBS-related diseases in mothers and infants and promote maternal and infant health.

This project intends to explore the characteristics of vaginal microbiota of GBS-colonized pregnant women in southern China, the impact of IAP prevention of GBS-EOD on vaginal flora, and the effect of IAP prevention of GBS-EOD on intestinal flora and immune production in offspring, so as to improve the ability to prevent and treat GBS-related diseases in mothers and infants and promote maternal and infant health.

Study Type

OBSERVATIONAL

Enrollment

492

Conditions

Microbiome, Human

Interventions

antibioticDRUG

For pregnant women with GBS colonization, antibiotics are used to prevent infection

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Pregnant women are 18 to 40 years; * 35 to 41 weeks of pregnancy; * Singleton pregnancy; * Plan for vaginal delivery and postpartum care in the research hospital; * Pregnant women who volunteered to participate in the study. Exclusion Criteria: * Have infectious diseases, serious infections and clinical diseases; * Use of antibiotics in the past 2 weeks; * Long-term use of drugs due to digestion, immunity, blood, chronic diseases; * Sexual behavior, vaginal douching and topical medication within 24 hours before sampling; * Any medical or non-medical condition that the investigator considers inappropriate to participate.

Locations (1)

Zhujiang Hospital

Guangzhou, Guangdong, China

Outcomes

Primary Outcomes

Intestinal flora

Analyze the effect of intrapartum antibiotics on the prevention of early-onset group B streptococcal diseases on the gut microbiome of offspring.

Time frame: The offspring are born on the 3rd day after birth

Secretory IgA

Analyze the effect of intrapartum antibiotics on the prevention of early-onset group B streptococcal diseases on the secretory IgA of offspring.

Time frame: The offspring are born on the 3rd day after birth

Calprotectin

Analyze the effect of intrapartum antibiotics on the prevention of early-onset group B streptococcal diseases on the cailprotectin of offspring.

Time frame: The offspring are born on the 3rd day after birth

Intestinal flora

Analyze the effect of intrapartum antibiotics on the prevention of early-onset group B streptococcal diseases on the gut microbiome of offspring.

Time frame: The offspring are born on the 42nd day after birth

Secretory IgA

Analyze the effect of intrapartum antibiotics on the prevention of early-onset group B streptococcal diseases on the secretory IgA of offspring.

Time frame: The offspring are born on the 42nd day after birth

Calprotectin

Analyze the effect of intrapartum antibiotics on the prevention of early-onset group B streptococcal diseases on the cailprotectin of offspring.

Time frame: The offspring are born on the 42nd day after birth

Secondary Outcomes

The effect of IAP to prevent GBS-EOD.

Data from ClinicalTrials.gov

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