The aim of the current study is to evaluate the effects of the Hypotension Prediction Index (HPI) on the degree of intraoperative hypotension in patients undergoing free flap surgery. The hypothesis is that implementation of the HPI algorithm will reduce the time-weighted average (TWA) intraoperative hypotension below a threshold of 65 mmHg (16), and to reveal the relationship between the episodes of hypotension and free flap viability and function.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
206
Hemodynamic perioperative monitoring with the Hypotension Prediction Index
Department of Anesthesiology, Intensive Therapy and Pain Management
Poznan, Poznań, Poland
RECRUITINGTWA Mean Arterial Pressure (MAP) < 65 mmHg
TWA - MAP \< 65 mmHg - time weighed average = (depth of hypotension in millimeters of mercury below a MAP of 65 mmHg x time in minutes spent below MAP of 65mmHg)/total duration of operation in minutes
Time frame: From the beginning of the anesthesia to the end of anesthesia
TWA - MAP < 60 mmHg
time weighed average = (depth of hypotension in millimeters of mercury below a MAP of 60 mmHg x time in minutes spent below MAP of 60 mmHg)/total duration of operation in minutes
Time frame: From the beginning of the anesthesia to the end of anesthesia
TWA - MAP < 55 mmHg
time weighed average = (depth of hypotension in millimeters of mercury below a MAP of 55 mmHg x time in minutes spent below MAP of 55 mmHg)/total duration of operation in minutes
Time frame: From the beginning of the anesthesia to the end of anesthesia
30 day mortality
30 day mortality
Time frame: 30 days
Length of hospitalisation
Length of hospitalisation
Time frame: From date of randomisation to the date of hospital discharge or date of death, whichever came first, assesed up to 3 months
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