The Impact of Past Coronavirus Disease 19 (COVID-19) Infection on the Live Birth Rates of Frozen Embryo Transfer Cycles

ShangHai Ji Ai Genetics & IVF Institute820 enrolled

Overview

This is a prospective observational study. In this study, we aim to investigate the effect of a recent past Covid-19 infection on the live birth rate in the frozen embryo transfer cycles

Study Type

OBSERVATIONAL

Enrollment

820

Conditions

COVID-19 Frozen Embryo Transfer

Interventions

frozen embryo transferOTHER

transfer one or two embryos in frozen embryo transfer cycles

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 42 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Women aged 20-42 years at the time of ovarian stimulation for in vitro fertilization 2. Women have embryos frozen prior to COVID infection. Exclusion Criteria: 1. Previous COVID infection before oocyte retrieval 2. Recipient of oocyte donation 3. Undergoing preimplantation genetic testing 4. Presence of hydrosalpinx or endometrial polyp which is not surgically treated

Locations (1)

ShangHai JIAI Genetics&IVF Institute

Shanghai, China

Outcomes

Primary Outcomes

live birth rate

live birth rate of the frozen embryo transfer cycle (\>22 weeks of gestation)

Time frame: a live birth after 22 weeks gestation

Secondary Outcomes

serum hCG level

Time frame: a blood pregnancy test is performed 14 days after the embryo transfer

clinical pregnancy

presence of intrauterine gestational sac on ultrasound

Time frame: presence of intrauterine gestational sac on ultrasound at 6 weeks of pregnancy

ongoing pregnancy

viable pregnancy beyond gestation 12 weeks

Time frame: viable pregnancy beyond gestation 12 weeks

biochemical pregnancy

positive blood pregnancy test not followed by clinical pregnancy

Time frame: positive blood pregnancy test not followed by clinical pregnancy during 12 weeks gestation

implantation rate

number of gestational sacs per embryo transferred

Time frame: number of gestational sacs per embryo transferred during 4 weeks of pregnancy

multiple pregnancy

more than one intrauterine sacs on scanning

Time frame: multiple pregnancy beyond gestation 12 weeks

ectopic pregnancy

pregnancy outside the uterine cavity

Time frame: ectopic pregnancy during 12 weeks gestation

Data from ClinicalTrials.gov

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