The goal of this observational study is to assess the changes of ascending aortic diameter in patients undergoing transcatheter aortic valve replacement. The main questions it aims to answer are: 1. whether the ascending aortic diameter increases or remains stable after transcatheter aortic valve replacement, especially in patients with preoperative ascending aortic dilatation; 2. the determinants of postoperative ascending aortic dilatation.
Ascending aortic (AA) dilatation occurs frequently in patients with aortic stenosis (AS). For patients who are candidates for transcatheter aortic valve replacement (TAVR), simultaneous repair of a dilatated AA is technically difficult. As the indications for TAVR have extended to low-risk patients and patients with bicuspid aortic valve , AA dilatation should be considered as a new criterion to refine risk stratification in patients undergoing TAVR. In this observational study, we aim to evaluate the changes of AA diameters and identify the determinants post-TAVR AA dilatation.
Study Type
OBSERVATIONAL
Enrollment
480
All patients undergo transfemoral transcatheter aortic valve replacement for aortic stenosis
National Center for Cardiovascular Disease, China & Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College
Beijing, Beijing Municipality, China
RECRUITINGRate of ascending aortic dilatation
The change of AA diameters (before the procedure and at the latest follow-up) divided by the follow-up period.
Time frame: 1-year and 2-year
Rate of all-cause mortality
All-cause mortality during the follow-up period
Time frame: 1-year and 2-year
Rate of adverse aortic events
Aortic dissection, aortic rupture, and sudden death not attributable to other causes.
Time frame: 1-year and 2-year
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