Liver failure is the most severe form of liver damage caused by viral, alcoholic, drug-related and ischemia-reperfusion factors, often combined with extrahepatic organ damage, resulting in a high mortality rate. This study intends to construct a real-world case registry database of inpatients with liver failure based on an electronic clinical data collection system through a multicenter collaborative network to study the clinical characteristics, epidemiology of bacterial and fungal infections, the impact of sarcopenia on clinical prognosis, and optimization of treatment strategies such as antiviral and artificial liver in Chinese inpatients with liver failure. The cohort and experience generated from this study will be used as a support for a series of future studies to focus on clinical issues such as infection, end-stage liver disease combined with organ failure, and early warning of critically ill patients.
Study Type
OBSERVATIONAL
Enrollment
500
Acute onset, no history of underlying liver disease, liver failure characterized by degree Ⅱ or above hepatic encephalopathy developed within 2 weeks
The onset was acute, with no history of underlying liver disease, and clinical manifestations of liver failure appeared between 2 and 26 weeks
On the basis of chronic liver disease, the clinical manifestations of acute liver decompensation and liver failure appear in a short period
First Affiliated Hospital of Xi'an Jiaotong University
Xi'an, Shaanxi, China
RECRUITINGAnkang Central Hospital
Ankang, China
RECRUITINGXiangya Hospital of Central South University
Changsha, China
NOT_YET_RECRUITINGHanzhong 3201 Hospital
Hanzhong, China
NOT_YET_RECRUITINGQilu Hospital of Shandong University
Jinan, China
NOT_YET_RECRUITINGFirst Hospital of Lanzhou University
Lanzhou, China
NOT_YET_RECRUITINGWeinan Central Hospital
Weinan, China
NOT_YET_RECRUITINGAir Force Medical University Tangdu Hospital
Xi'an, China
NOT_YET_RECRUITINGShaanxi provincial people's hospital
Xi'an, China
NOT_YET_RECRUITINGThe Second Affiliated Hospital of Xi'an Jiaotong University
Xi'an, China
RECRUITING...and 4 more locations
Overall survival
28-day survival rates without liver transplantation
Time frame: 28-day
Overall survival
90-day survival rates without liver transplantation
Time frame: 90-day
Disease progression
Incidence of complications and re-hospitalization at 48 weeks after discharge
Time frame: 48 weeks after discharge
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.