Optimal Exercise Frequency to Reduce Liver Fat in Centrally Obese Adults With Non-Alcoholic Fatty Liver Disease

Inclusion Criteria: 1. Cantonese, Mandarin, or English speaking Chinese; 2. Aged 18-69; 3. Male or female; 4. Centrally obese according to the Asian-specific cut-off (waist circumference ≥90 cm for males; ≥80 cm for females) and with BMI ≥23; 5. With NAFLD (defined as \>5% intrahepatic triglycerides assessed by 1H-MRS); 6. Willing to participate in exercise training to improve NAFLD. Exclusion Criteria: 1. Regular exercise training (\>3 sessions of \>60 min of moderate-intensity exercise training weekly) in the past 6 months; 2. Medical history of cardiovascular disease, chronic pulmonary or kidney disease, heart failure, cancer, and/or liver disease except NAFLD; 3. Somatic conditions that limit exercise participation (e.g., limb loss); 4. Impaired mobility due to chronic disease (e.g., chronic arthritis/osteoarthritis, neurological, musculoskeletal, and autoimmune diseases); 5. Daily smoking habit; 6. Excess alcohol consumption (daily ≥20 g of alcohol for men and ≥10 g for women) in the past 1 year; 7. Consumption of certain drugs (e.g., tamoxifen and estrogen) known to be secondary causes of steatosis; 8. Surgery, therapy, or medication for obesity or weight loss in the past 6 months (e.g., gastric bypass, gastric band, sleeve gastrectomy, gastric reduction duodenal switch, or dietitian-prescribed dietary program); 9. Physical changes that considerably affect body composition and weight (e.g., anorexia nervosa, bulimia nervosa, prolonged gastrointestinal and digestive disorders) during the study period.