AMIC vs. MFx in the Ankle

Inclusion criteria: * Signed written informed consent * Diagnosis of symptomatic osteochondral or chondral lesion of the talus, deemed by surgeon amenable to arthroscopic treatment with debridement and microfracture * Age of 18-65 years * Subject is willing and able to comply with all study procedures, including visits, diagnostic procedures, the rehabilitation protocol and responding to patient questionnaire follow up Exclusion criteria: * Lesions smaller 1 square centimeters and greater than 4 square centimeters based on the MRI * Malalignment which is not corrected prior to or as part of same surgery * Established significant hindfoot arthritis * Patients who are unable to have an MRI scan * Chronic inflammatory arthritis or infectious arthritis * History of autoimmune disease or immunodeficiency * History of connective tissue disease * Intra-articular steroid use within the 3 months prior to enrolment * Other intra-articular injections (e.g., hyaluronic acid) within 3 months prior to enrolment * The patient is currently being treated with radiation, chemotherapy, immunosuppression, or systemic steroid therapy with a dose equivalent to more than 5 mg prednisolone * Pregnancy or lactation * Enrolled in another study, involved in the study (as a researcher/investigator/sponsor), or relative of someone directly involved in the clinical investigation * Active infection of the index ankle * Has been prescribed medication to treat osteoporosis * Any disorder or impairment that would interfere with evaluation of outcomes measures, such as neurological, degenerative muscular, psychiatric, or cognitive conditions