Oxycodone in Combination With Parathoracic Nerve Block is Used for Postoperative Analgesia in Lung Cancer

Qianfoshan Hospital159 enrolled

Overview

In this study, the effect of oxycodone combined with ultrasound-guided paravertebral nerve block on the postoperative analgesic effect of thoracoscopic lung cancer was investigated, and the effect and reasonable dose of oxycodone were explored, which provided a reference for the clinical multimodal analgesia after thoracoscopic lung cancer surgery.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

159

Conditions

Oxycodone

Interventions

Oxycodone 1mg/kgDRUG

Test group 1 (OCA group):oxycodone 1mg/kg + flurbiprofen 50mg + ondansetron 16mg + 0.9% normal saline diluted to 100ml

Oxycodone 1.5mg/kgDRUG

Test group 2 (OCB group): oxycodone 1.5mg/kg + flurbiprofen 50mg + ondansetron 16mg + 0.9% normal saline diluted to 100ml.

SufentanilDRUG

Control group (SF group): sufentanil 2ug/kg + flurbiprofen + ondansetron 16mg + 0.9% normal saline diluted to 100ml.

Eligibility

Sex: ALLMin age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Male or female, age \> 60 years 2. Patients undergoing thoracoscopic lobectomy 3. ASA (American Academy of Anesthesiologists) Grades I-III 4. There were no obvious abnormalities in heart, liver, and kidney function 5. Sign the informed consent form for this clinical study Exclusion Criteria: 1. History of oxycodone or sufentanil allergy 2. Renal or hepatic dysfunction 3. History of drug or alcohol abuse 4. Psychiatric disorders: schizophrenia, epilepsy, Parkinson's disease, myasthenia gravis 5. Those who have difficulty communicating due to coma, severe dementia, speech barrier, or those who cannot cooperate due to other diseases. 6. People with head trauma or other brain diseases -

Outcomes

Primary Outcomes

The main indicators were NRS scores at rest and cough at 24 h postoperatively.

NRS (numerical rating scale) is composed of 11 numbers from 0 to 10, and patients use 11 numbers from 0 to 10 to describe the intensity of pain, and the higher the number, the more severe the pain.

Time frame: at 24h after surgery

Secondary Outcomes

Time to double-lumen tracheal extraction

Time frame: Within two hours after surgery

NRS score at rest and cough

NRS (numerical rating scale) is composed of 11 numbers from 0 to 10, and patients use 11 numbers from 0 to 10 to describe the intensity of pain, and the higher the number, the more severe the pain.

Time frame: at 2h , 4h, 12h, 48h after surgery

sedation score (Ramsay sedation score)

The Ramsay sedation score is the most widely used sedation scoring criterion in clinical practice. It is divided into six levels, reflecting three levels of wakefulness and three levels of sleep. The higher the level, the deeper the level of sedation.

Time frame: at 2 h , 4 h , 12 h ,24 h,48 h postoperatively

sufentanil consumption

Time frame: Within 48 hours after surgery

oxycodone consumption

Time frame: Within 48 hours after surgery

analgesic pump compressions

Time frame: Within 48 hours after surgery

Central Contacts

Pengcai Shi, Chief physician

CONTACT

13791126828 shipc1997@163.com

Data from ClinicalTrials.gov

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