ARIADNE: A Study of Weight Loss for Diabetes Treatment and Wellbeing

Inclusion Criteria: * Willing and able to give informed consent, can communicate in English * Age between 18 and 65 years inclusive * Live in England * BMI ≥27 kg/m2 or higher (adjusted to ≥25 kg/m2 for people of Black, Asian and minority ethnic origin) * Diagnosed with T2D within 6 years prior to the day of screening * Global EDE-Q scores ≥2.67 * To have an HbA1c taken in the last 12 months * Latest HbA1c ≥43 mmol/mol (6.1%) and ≤87 mmol/mol (10%) if on diabetes medication OR latest hbA1c ≥ 48 mmol/mol (6.5%) and ≤87 mmol/mol (10%), if not on diabetes medication. * If diagnosed with type 2 diabetes more than 1 year since day of screening, the participant must have attended their GP surgery for monitoring/ diabetes review when last offered * Commit to continue annual reviews with their GP, even if T2D remission is achieved Exclusion Criteria: The participant must not enter the study if ANY of the following apply: * Current or previous clinical diagnosis of an eating disorder * Combination of EDE-Q ≥4 AND a CIA score ≥16 at screening * Currently participating in a structured weight loss programme or self-reporting that they have lost \>10% of their body weight in the last 3 months * Insulin use * Known kidney disease of stage 3/4/5 or eGFR \<60 mls/min/1.73 m2 within the last 12 months * Active substance use disorder * Active cancer other than skin cancer * Known proliferative retinopathy that has not been treated * Porphyria * Undergone or is awaiting bariatric surgery * Myocardial infarction or stroke within previous 6 months * Severe heart failure defined as equivalent to the New York Heart Association (NYHA) grade 3 or 4 * Active liver disease (not including non-alcoholic fatty liver disease) * Pregnant, breastfeeding, or planning to become pregnant during the course of the study * Soy or milk or fish allergy, lactose intolerance, or following a vegan diet * People currently participating in another study or clinical trial of a CTIMP/non-CTIMP