Comparison of A-PRF vs Bone Wax in Hemostasis, Pain Relief and Healing Following Exodontia

Altamash Institute of Dental Medicine129 enrolled

Overview

The goal of this clinical trial is to compare the pain relief and healing effect of A-PRF and Bone-wax in patients having mandibular tooth-extractions. The main question\[s\] it aims to answer are: In the perspective of improvement in pain and healing; * Does A-PRF performs better than control group? * Does Bone-wax performs better than control group? * Healing index and Pain scale score Comparison of A-PRF and Bone-wax; if one is better than the other? Participants will be asked to give resoponse to a post-operative symptom severiety (PoSSe) scale. An investigator will score the patient's extraction for hemostasis and on healing index \[describe the main tasks participants will be asked to do, treatments they'll be given and use bullets if it is more than 2 items\]. If there is a comparison group: Researchers will compare \[insert groups\] to see if \[insert effects\].

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

129

Conditions

Post-Extraction Socket Hemostasis Post-Extraction Socket Pain Relief Post-Extraction Socket Healing

Eligibility

Sex: ALLMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * All patients who need extraction of mandibular posterior teeth * Overall, systemically healthy individuals (Established based on history, i.e., patients who do not take medicine for any systemic condition). * INR within normal range. Exclusion Criteria: * Patients with a diagnosed systemic condition. * Patients who are immunocompromised. * Patients who are unwilling to participate or withdraw from the study. * Patients who fail to report on the seventh and twenty-first post-extraction day. * Patients with physical or mental impairments who need assistance in taking their medications.

Outcomes

Primary Outcomes

Pain Relief on VAS

Patients receiving any of the intervention will be evaluated at just before, 3rd, 7th and 21st day of dental extraction on Visual Analogue Scale (VAS).

Time frame: 21 days

Extraction socket healing

Patients receiving any of the intervention will be evaluated at 3rd, 7th and 21st day of dental extraction on Healing index by Landry et al.

Time frame: 21 days

Secondary Outcomes

Hemostasis

The post-operative bleeding will be evaluated 30 minutes after the placement of the last suture as: * No bleeding * Mild Bleeding: bleeding that stopped spontaneously or with minimal local compression. * Severe Bleeding: bleeding that did not stop with the previous measures and that required local adrenaline or continuous local compression using gauze pack soaked in the corresponding antifibrinolytic agent until the bleeding stops

Time frame: 30 minutes