Genetic Disorders of Obesity Program Database

Baylor College of Medicine500 enrolled

Overview

This study collects data on children with severe, early-onset obesity.

Children and adolescents who have suffered from severe weight gain prior to 5 years of age and who are seen in the Genetic Disorders of Obesity Program at Texas Children are asked to participate in a prospective, observational study. The investigators collect demographic information, body measurements, medical/family history, as well as other questionnaires. Additionally, genetic information, medical lab results, and responses to treatment options are collected. The goal of the study is to determine if the investigators can better understand which children would benefit from testing and further workup as well as to understand how obesity develops in these children and adolescents.

Study Type

OBSERVATIONAL

Enrollment

500

Conditions

Obesity, Childhood Genetic Disease

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * For individuals 2 years and older, BMI \> 97 percentile * For individuals \< 2 years old, weight-to-length ratio \> 95th percentile Exclusion Criteria: * No other exclusion criteria

Locations (1)

Baylor College of Medicine

Houston, Texas, United States

RECRUITING

Outcomes

Primary Outcomes

Prevalence of genetic causes of severe, early-onset obesity

We will measure the number of genetic variants identified in clinical testing

Time frame: through study completion, an average of 10 years

Secondary Outcomes

Change in BMI over time

BMI in kg/m2 will be documented over time. BMI is calculated using weight and height

Time frame: through participant completion, an average of 2 years

Central Contacts

Stephanie Sisley, MD

CONTACT

713-798-0391 Sisley.lab@bcm.edu

Data from ClinicalTrials.gov

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