This observational study aims to detect levels of iron, alpha-synuclein, and soluble lymphocyte activation gene 3 in acute ischemic stroke patients. And to see expressions of iron, alpha-synuclein, and lymphocyte activation gene 3 in the brain tissue of ischemic rats. The main questions it aims to answer are: * Is there an association between iron and alpha-synuclein accumulation in ischemic stroke? * Is there any change in soluble lymphocyte activation gene levels in ischemic stroke and if these levels are related to stroke severity and infarction size? . Can soluble lymphocyte activation gene levels be used as an early biomarker to diagnose ischemic stroke?
Study Type
OBSERVATIONAL
Enrollment
48
Serum iron levels in study groups
α-syn levels in RBCs
sLAG-3 in the serum of study groups
Brain CT of patients after admission
Iron in brain homogenate of rats
α-syn expression in rat's brain
LAG-3 expression in rat's brain
intramuscular deferoxamine (200 mg/kg) injection to rats
Aswan University Hospital
Aswān, Egypt
Iron levels
Serum iron levels in ischemic patients and control
Time frame: 6 months
Alpha-synuclein levels
Alpha-synuclein levels in RBCs in ischemic patients and control
Time frame: 6 months
Levels of Soluble lymphocyte activation gene-3
Serum soluble lymphocyte activation gene-3 in ischemic patients and control
Time frame: 6 months
levels of iron, alpha-synuclein, and soluble lymphocyte activation in relation to stroke severity and infarction size
stroke severity will be evaluated by the National Institutes of Health Stroke Scale (NIHSS) and size of infarction will be detected by brain CT
Time frame: 6 months
Iron levels in brain of rats
Iron levels in brain homogenate of rats in the three rat groups
Time frame: 2 months
Levels of Alpha-synuclein expression in brain of rats
Alpha-synuclein expression in brain of rats in different groups
Time frame: 2 months
Levels of Lymphocyte activation gene-3 expression in brain of rats
lymphocyte activation gene-3 expression in brain of rats in different groups
Time frame: 2 months
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