The Influence of Exercise and Hydration to the Pharmacological Response to Inhaled Terbutalin and Salbutamol in Men

Vibeke Backer

Overview

To investigate the effects of dehydration and exercise for the urine secretion of beta2-agonists.

No studies have examined the influence of factors such as exercise and dehydration on the pharmacokinetic profile of asthmatic drugs (beta2-agonists). Exercise may modify the metabolism and excretion of drugs, and sweat loss during exercise can result in dehydration, both affecting the urine concentration of the drug.

Study Type

INTERVENTIONAL

Allocation

Purpose

OTHER

Masking

DOUBLE

Conditions

Healthy

Interventions

ExerciseBEHAVIORAL

Exercise vs non-exercise

Eligibility

Sex: MALEMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * men * aerobic capacity more than 50ml / min / kg * more than 5h training pr week Exclusion Criteria: * smokers * allergy for the medicine * chronic diseases

Locations (1)

Department of Respiratory Medicine, L, Bispebjerg Hospital,

Copenhagen, NV, Denmark

Outcomes

Primary Outcomes

Urine concentration of salbutamol and terbutalin

Time frame: 7 days

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.