Comparison of Tofacitinib and Prednisolone in the Treatment of Active Takayasu's Arteritis

Inclusion Criteria: 1. Patients aged between 18-65 years old; 2. Fulfilled the classification criteria of Takayasu's arteritis by ACR 1990; 3. Active TAK: defined by the definition of active disease in the recommendations released by EULAR in 2018 or Kerr's criteria by NIH; 4. Patients who signed the informed consent form. Exclusion Criteria: 1. Patients who failed or intolerant to either tofacitinib or its similar drugs; 2. Patients with severe liver disease defined by the serum ALT or AST elevated more than 2 times the upper limits; 3. Not well controlled diabetes; 4. Moderate and severe hyperlipedimia; 5. Patients with history of thrombus; 6. Uncontrolled heart failure od renal dysfunction (eGFR \<30ml/min); 7. Patients with active infection, including tuberculosis, hepatitis B and C, HIV infection, bacterial or fungal infection; 8. Upper GI bleeding happened in 3 months before enrollment; 9. Refractory hypertension; 10. Pregnant or intended to be pregnant recently; 11. Severe coronary artery involvement demonstrated by CTA; 12. Severe cranial or cervical or renal artery diseases that need surgery; 13. Patients that should not be included judged by the investigator.