Evaluate the Effect of TPN171H on the QT/QTc Interval in Healthy Volunteers

Inclusion Criteria: 1. Age 18-45 years old, both male and female; 2. Weight: male ≥ 50 kg, female ≥ 45 kg, 19 kg/m2 ≤ BMI ≤26 kg/m2 3. Three 12-lead ECG examinations (the average of three measurements will be used to determine eligibility), QTcF≤450 ms, PR interval ≤200 ms, and QRS duration \<120 ms; 4. Reliable contraceptive measures will be taken from the signing of the informed consent to 3 months after the medication, and there is no plan to donate sperm or eggs. The specific contraceptive measures are detailed in the appendix. 5. Able to understand the procedures and methods of this trial, willing to strictly abide by the clinical trial protocol to complete this trial, and voluntarily sign the informed consent. Exclusion Criteria: 1. Known allergic history to the investigational drug and any of its components or related preparations; 2. People with allergic diseases, food allergies or allergic constitutions; 3. have a history of risk factors for torsdos de pointes, or have a family history of short QT syndrome, long QT syndrome, unexplained sudden death in young adulthood (≤40 years old), drowning or sudden infant death syndrome in first-degree relatives (i.e., biological parents, siblings or children); 4. Previous history of hyperkalemia, hypokalemia, hypermagnesemia, hypomagnesemia, hypercalcemia or hypocalcemia; 5. Those who have definite diseases of the central nervous system, cardiovascular system, digestive system (including those with moderate or severe fatty liver on B-ultrasound examination), respiratory system, urinary system, blood system, and metabolic disorders that require medical intervention or other diseases that are not suitable for clinical trials (such as psychiatric history, etc.); 6. Patients with blurred vision or history of ophthalmology (such as abnormal color vision, retinitis pigmentosa, macular degeneration); 7. Patients with a history of postural hypotension; 8. Patients with a history of acute respiratory infection or acute illness within 14 days before screening; 9. Those who had donated blood or lost ≥400 mL of blood within 3 months before screening; 10. Use of any drugs that inhibit or induce liver metabolism of drugs (such as: inducers - barbiturates, carbazepine, phenytoin, glucocorticoids, omeprazole; Inhibitors -SSRI antidepressants, cimetidine, diltiazem, macrolides, nitroimidazole, sedatives and hypnotics, verapamil, fluoroquinolones, antihistamines); 11. Those who have taken any prescription drugs, non-prescription drugs, health care products, vitamins and Chinese herbal medicines within 14 days before screening; 12. Consuming grapefruit, grapefruit, pitaya, mango and other fruits or related products that affect metabolic enzymes within 7 days before screening; 13. Intake of caffeine-rich or xanthine-rich beverages or foods (such as coffee, strong tea, chocolate, cola, etc.) within 48 h before screening; 14. Those who participated in other drug clinical trials within 3 months before screening; 15. Current or former drug users or alcohol addicts, current or former alcoholics (drinking more than 14 standard units per week). 1 standard unit containing 14g of alcohol (e.g. 360 mL beer or 45 mL spirits with 40% alcohol or 150 mL wine), or a positive breath test for alcohol; 16. Those who smoked more than 10 cigarettes per day in the previous 3 months were screened; 17. Physical examination, abnormal vital signs (ear temperature \>37.5℃, respiratory rate \>20 beats/minute, pulse rate \>100 beats/minute, systolic blood pressure ≥140 mmHg or \<90 mmHg, diastolic blood pressure ≥90 mmHg or \<50 mmHg), abnormal and clinically significant laboratory results, and those who have an impact on the evaluation of this trial; 18. Laboratory tests showed that serum potassium, magnesium and calcium were beyond the normal range and the abnormalities were judged by the researchers to be clinically significant; 19. Hepatitis B surface antigen (HBsAg), hepatitis C virus (HCV) antibody, syphilis antibody (TPPA) or human immunodeficiency virus (HIV) antibody positive; 20. Abnormal chest X-ray (anteroposterior and lateral view) or lung CT results with clinical significance; 21. Women with positive blood pregnancy test (applicable to women) or lactating women; 22. Those who have other factors that the investigator considers unsuitable for participation in the trial.