GnRH antagonist protocol is currently a good strategy for controlled ovarian stimulation in women with PCOS undergoing IVF/ICSI cycles. Finding a protocol that can be a better alternative will help in improving the success rate of IVF/ICSI cycles
Progesterone has potent restraint on hypothalamus-pituitary-ovarian axis. It acts on unidentified hypothalamic pulse oscillator neurons. In turn, it acts on gonadotropins releasing hormone (GnRH) secreting neurons leading to inhibition of GnRH secretion. This results in inhibition of both luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion from anterior pituitary. The effect of progesterone appears to decrease GnRH pulse frequency which results in slowing down LH pulse frequency and reducing LH plasma concentrations
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
79
progestin primed ovarian stimulation protocol
20 mg oral dose of dydrogesterone (Duphaston, Abbott)
0.25 mg of Cetrotide (gonadotropin releasing hormone (GnRH) antagonist)
Zagazig University
Zagazig, Egypt
RECRUITINGEfficacy (Number of MII oocytes retrieved)
this outcome means to measure Percentage (number) of MII oocytes retrieved During our study
Time frame: 3 months
Efficacy (Maturation index)
Maturation index will be calculated: Rate of metaphase-II oocytes (MII) to total oocytes
Time frame: 3 months
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