Feasibility Study of Intra-Tumoral Lipopolysaccharide Immunotherapy for Intra-Abdominal Tumors

Inclusion Criteria: 1. Males or females age 18 to 99 years 2. Pre-menopausal women less than or equal to18 years of age must have a negative urine/serum pregnancy test prior to standard-of-care surgery and investigational treatment. 3. Participants must have an advanced intra-abdominal tumor, including metastatic or recurrent, biopsy-proven, digestive tract tumors. 4. Participants must have at least two index non-visceral intra-abdominal tumors that are grossly visible, \>1cm3 in volume, and amenable to biopsy and injection of investigational drug or control solution at the time of laparoscopy. 5. Participants must be planning or scheduled to undergo a standard-of-care abdominal laparoscopic surgical procedure at AGH or WPH and be potentially eligible for a second, definitive operation to remove the tumor(s) pending the findings during laparoscopy. 6. Must be able to read and understand English and consent for themselves Exclusion Criteria: 1. Pregnant or lactating females 2. Investigational drug use within 30 days prior to enrollment. 3. Immunosuppressive medication including corticosteroids within 30 days prior to enrollment. 4. Active chemotherapy or radiotherapy within 4 weeks of investigational agent injection. 5. Active infection requiring systemic therapy or causing fever \>38.1 degree C or unexplained fever \>38.1 degree C within seven days prior to investigational agent injection 6. Laboratory abnormalities, drawn according to standard clinical care in anticipation of upcoming surgery outside the following limits: AST/SGOT \> 1.5 times the upper limit of normal ALT/SGPT \> 1.5 times the upper limit of normal Total bilirubin \> 1.5 times the upper limit of normal Creatinine \> 1.5 times the upper limit of normal Hemoglobin \< 9 gm/dL White blood cell count \< 3,000/ mm3 Platelet count \< 70,000/mm3 INR \>1.5 times the upper limit of normal PTT \>1.5 times the upper limit of normal 7. History of allergic reaction to the investigational agent carrier solution. 8. Medical contra-indication or allergic reaction to acetaminophen or NSAIDs. 9. Participants who, in the opinion of the Investigator, may be non-compliant with study schedules or procedures. 10. Adverse events from prior therapy that have not resolved to CTCAE version 5 grade \< and equal to1 prior to enrollment