Transcranial Direct Current Stimulation of the Primary Motor Cortex to Treat Levodopa-induced Dyskinesias

Fondazione Policlinico Universitario Agostino Gemelli IRCCS32 enrolled

Overview

The main objective of the study is to evaluate the efficacy of 10 sessions of transcranial direct current stimulation of the primary motor cortex to reduce levodopa-induced dyskinesia

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Parkinson Disease

Interventions

Transcranial direct current stimulationDEVICE

Ten sessions of transcranial direct current stimulation over primary motor cortex to treat levodopa-induced dyskinesia

Eligibility

Sex: ALLMin age: 30 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients with diagnosis of idiopathic Parkinson's disease according to Movement Disorder Society (MDS) criteria and levodopa-induced dyskinesia; * age between 30 and 80 years; * ongoing therapy with levodopa; * fulfillment of requirements for the application of transcranial magnetic stimulation (TMS), assessed by completion of the TMS screening questionnaire. Exclusion Criteria: * patients unable to give informed consent; * cognitive impairment (MMSE ≤ 24); * history of epilepsy; * pregnant women.

Locations (1)

Flavia Torlizzi

Rome, Italy

RECRUITING

Outcomes

Primary Outcomes

Reduction of dyskinesia

Change in the total score of part III of the Unified Dyskinesia Rating Scale (range 0-112, 112 is the worse outcome) in on motor state at the assessment made three days after the end of treatment compared with the assessment made at baseline in the groups of patients treated with tDCS and sham-stimulation, respectively

Time frame: 15 days

Central Contacts

Francesco Bove, MD

CONTACT

+390630156433 francesco.bove@policlinicogemelli.it

Data from ClinicalTrials.gov

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