In resectable gastric cancer participants who received curative surgery, to early and more accurately detect peritoneal carcinomatosis or occult metastasis is important. Also, investigators will look at CTC numbers in different timings after operation, to investigate the possibility of early detection for peritoneal carcinomatosis or occult metastasis. Also, this study will correlate the relationship of CTC and participants' survival.
Circulating tumor cells (CTCs) are an emerging "liquid biopsy" that provide prognostic value for various types of solid cancer on early recurrence and survival. The evaluation of CTCs might be a useful strategy to predict tumor progression and prognosis in Gastric adenocarcinoma (GC). Previous study has shown that the frequency of CTC detection was higher in advanced GC than early GC, in poorly differentiated GC than well/moderately differentiated GC, and in GC with lymphatic metastasis than that without lymphatic metastasis. However, the impact of CTCs in the detection of PM in GC is still under debate. Peritoneal metastasis (PM) is highly related to recurrence and metastasis in GC; therefore, it was significantly related to disease free and overall survival of participants. Consequently, several important questions and goals will be answered by this study: To elucidate the clinical relationship between CTCs and PM in GCs before the operation; therefore, it could be an indicator of prophylactic during operation, which may possibly prolong the disease free and overall survival. To establish a good model to follow-up a specific surface marker on CTCs, which could be possibly utilized as a more sensitive marker, comparing with CEA or image study, to more accurately detect the early recurrence or metastasis in GC. To verify that dynamically monitoring CTCs status and changes during long-term follow-up and anti-cancer treatment are feasible and clinically meaningful to survival or treatment responses.
Study Type
OBSERVATIONAL
Enrollment
150
Chang Gung Memorial Hospital
Taoyuan, Taiwan
RECRUITINGPercentage of disease recurrence
Circulating tumor cells detection in different time after operation, to evaluate the clinical relationship between Circulating tumor cells and disease recurrence.
Time frame: Baseline
Percentage of disease recurrence
Circulating tumor cells detection in different time after operation, to evaluate the clinical relationship between Circulating tumor cells and disease recurrence.
Time frame: Post-operation within 3 days
Percentage of disease recurrence
Circulating tumor cells detection in different time after operation, to evaluate the clinical relationship between Circulating tumor cells and disease recurrence.
Time frame: Post-operation day 4 - 4 weeks
Percentage of disease recurrence
Circulating tumor cells detection in different time after operation, to evaluate the clinical relationship between Circulating tumor cells and disease recurrence.
Time frame: Post-operation 3 months
Percentage of disease recurrence
Circulating tumor cells detection in different time after operation, to evaluate the clinical relationship between Circulating tumor cells and disease recurrence.
Time frame: Post-operation 6 months
Percentage of peritoneal seedings
Circulating tumor cells detection in different time after operation, to early detect peritoneal carcinomatosis or occult metastasis.
Time frame: Baseline
Percentage of peritoneal seedings
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Circulating tumor cells detection in different time after operation, to early detect peritoneal carcinomatosis or occult metastasis.
Time frame: Post-operation within 3 days
Percentage of peritoneal seedings
Circulating tumor cells detection in different time after operation, to early detect peritoneal carcinomatosis or occult metastasis.
Time frame: Post-operation day 4 - 4 weeks
Percentage of peritoneal seedings
Circulating tumor cells detection in different time after operation, to early detect peritoneal carcinomatosis or occult metastasis.
Time frame: Post-operation 3 months
Percentage of peritoneal seedings
Circulating tumor cells detection in different time after operation, to early detect peritoneal carcinomatosis or occult metastasis.
Time frame: Post-operation 6 months
overall survival time
To correlate the relationship of circulating tumor cells and long-term survival time.
Time frame: Post-operation 1 year.
overall survival time
To correlate the relationship of circulating tumor cells and long-term survival time.
Time frame: Post-operation 2 year.
Progression-free survival
To correlate the relationship of circulating tumor cells and Progression-free survival.
Time frame: Post-operation 1 year.
Progression-free survival
To correlate the relationship of circulating tumor cells and Progression-free survival.
Time frame: Post-operation 2 year.