Improving Outcomes of Respiratory Patients With Exertional Hypoxemia

Changi General Hospital56 enrolled

Overview

The primary aim of this pilot randomized controlled trial is to determine feasibility of the proposed pulmonary rehabilitation intervention.

In this pilot randomized controlled trial, our primary aim is to determine feasibility of the proposed intervention.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Pulmonary Rehabilitation

Interventions

High flow oxygenDEVICE

Use of HFO

Usual careOTHER

Room air or normal flow oxygen

Eligibility

Sex: ALLMin age: 21 YearsMax age: 100 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 21 years and above * Presence of exertional hypoxemia during 1-minute sit-to-stand test * diagnosis of acute COPD exacerbation or Covid-19 pneumonia or exacerbation of bronchiectasis or exacerbation of interstitial lung disease * physically fit to participate in exercise therapy as determined by both the patient's physician and physiotherapist Exclusion Criteria: * uncontrolled severe medical conditions * currently enrolled in a pulmonary rehabilitation trial * unsuitable for randomization as determined by the patient's physician

Locations (1)

Changi General Hospital

Singapore, Singapore

RECRUITING

Outcomes

Primary Outcomes

Changes in 1-minute sit to stand test

maximum number of sit to stand cycles in 1 minute

Time frame: 1 month

Secondary Outcomes

Changes in 30-second sit to stand test

maximum number of sit to stand cycles in 30 seconds

Time frame: 1 month, 3 month

Changes in respiratory symptoms

Modified Medical Research Council Dyspnea Scale. The scale ranges from 0 to 4 with a higher score indicating increasing breathlessness

Time frame: 1 month, 3 months

Changes in mood

Hospital Anxiety Depression Scale. The scale ranges from 0 to 21, A total subscale score of \>8 points indicates considerable symptoms of anxiety or depression.

Time frame: 1 month, 3 month

changes in quality of life

EQ-5D-5L

Time frame: 1 month, 3 month

Changes in lung function

Forced expiratory volume in 1 sec

Time frame: 1 month, 3 month

Changes in lung function

forced vital capacity

Time frame: 1 month, 3 month

Proportion of patients who still have exertional hypoxemia

Comparing the proportion of patients who still have exertional hypoxemia

Time frame: 1 month, 3 month

Central Contacts

Yingjuan Mok, MBBS

CONTACT

69366603 mok.yingjuan@singhealth.com.sg

Data from ClinicalTrials.gov

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