Intermittent Cefoxitin Administration Versus Loading Bolus Followed by Continuous Infusion for the Prevention of Surgical Site Infection in Colorectal Surgery

Inclusion Criteria: * Adult patients (≥18 years) * Undergoing colorectal surgery (predictable duration \> 90 min) Exclusion Criteria: * Patients with known history of hypersensitivity to cefoxitin or others beta-lactams * Patients with extreme severe obesity (defined by a body mass index greater than 50 kg/m2) * Patients with severe renal insufficiency (clearance creatinine \< 30ml/min) * Active bacterial infection at the time of surgery or recent antimicrobial therapy (up to 2 weeks before surgery) except for oral surgical antibiotic prophylaxis