The goal of this observational study is to compare cerebral perfusion patterns with pseudo-continuous arterial spin labeling (pCASL) and brain metabolism patterns with fluorodeoxyglucose-position emission tomography (FDG-PET) in patients with mild cognitive impairment (MCI) and subjective cognitive decline (SCD). The main questions it aims to answer are: * Do pCASL sequences identify hypoperfusion patterns that correlate well with FDG-PET hypometabolic patterns? * Are there differences in this correlation in terms of cerebrospinal fluid (CSF) profiles? * Can hypoperfusion patterns in pCASL predict conversion to dementia? Participants will undergo brain 3 Tesla magnetic resonance imaging (MRI), FDG-PET, lumbal puncture and blood collection to analyze amyloid beta and tau, yearly detailed neuropsychological tests for three years.
Study Type
OBSERVATIONAL
Enrollment
150
Brain 3 Tesla MRI with pCASL sequence
Fondazione IRCCS San Gerardo dei Tintori
Monza, MB, Italy
RECRUITINGCorrelation between brain hypoperfusion and brain hypometabolism at baseline
The investigators will correlate cerebral perfusion indices and standardized uptake value ratios (SUVr) ratios for each pre-specified region of interest (ROI) within statistical parametric mapping (SPM) Automatic Anatomic Labeling (AAL), after coregistration on T1 sequences
Time frame: Baseline
Correlation between brain hypoperfusion and brain hypometabolism at baseline according to CSF profile
The investigators will correlate cerebral perfusion indices and SUVr for each pre-specified ROI (region of interest) within SPM Automatic Anatomic Labeling (AAL), after coregistration on T1 sequences. This analysis will be done within subgroups according to CSF status according to amyloid beta, phosphorylated tau and total tau.
Time frame: Baseline
Differences among brain hypoperfusion patterns according to amyloid and tau status
The investigators will analyze differences in brain perfusion indices for each ROI among patients wit amyloid positive status, amyloid and tau negative status, and amyloid negative - tau positive status
Time frame: Baseline
Correlations between brain hypoperfusion and neuropsychological tests
The investigators will perform correlations between brain hypoperfusion indices for each ROI and various neuropsychological (NPS) test scores
Time frame: Baseline, 1 year, 2 years
Predictive properties of brain hypoperfusion and brain hypometabolism for conversion to dementia
The investigators will analyze correlations between each ROI hypoperfusion and conversion to dementia rates within the prespecified time frame. In case of significant associations, a receiver operating characteristic curve (ROC) analysis will be carried out to individuate optimal cut-offs for cerebral blood flow indices and SUVr to predict conversion of dementia
Time frame: 1 year, 2 years
Correlations between brain hypoperfusion and CSF and blood biomarkers
The investigators will perform correlations between brain hypoperfusion indices for each ROI and values of CSF and blood amyloid beta, phosphorylated tau and total tau
Time frame: Baseline
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