Coffee for Optimal Metabolite Profile

Chalmers University of Technology12 enrolled

Overview

The aim of this project is to evaluate metabolite profile after consumption of three types of coffee differing in type of bean, degree of roasting and preparation method. Metabolite profiles will be evaluated after a) a single dose b) 3-day consumption. The study will be carried out as a three-way cross-over design with three different types of coffee. Wash-out periods where participants consume their habitual diet are implemented between all intervention periods. The first day of intervention (single dose) includes postprandial measurements during 13 hours.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

DOUBLE

Enrollment

Conditions

Healthy

Interventions

DietOTHER

All intervention arms are coffee. Three different types of coffee is tested. Differences in type of bean, degree of roasting and preparation method.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Females and males * 18 to 80 years of age * Body mass index (BMI) 18.5-30.0 kg/m2 * Fasting glucose ≤ 6.1 mmol/l * Low density lipoprotein (LDL) cholesterol ≤ 5.30 mmol/l * Triglycerides ≤ 2.60 mmol/l * Signed informed consent Exclusion Criteria: * Food allergies or intolerances preventing consumption of any products included in the study. * Unable to sufficiently understand written and spoken Swedish to provide written consent and understand information and instructions from the study personnel. * Pregnant, lactating or planning a pregnancy during the study period. * Antibiotic use for the last 3 months. * Blood donation or participation in a clinical study with blood sampling within 30 days prior to screening visit and throughout the study. * History of stomach or gastrointestinal conditions (Inflammatory bowel disease, Chron's disease, malabsorption, colostomy, bowel resection, gastric bypass surgery etc.) * Previous major gastrointestinal surgery * Have type I diabetes * Thyroid disorder

Locations (1)

University of Gothenburg, Department of Food and Nutrition and Sport Science

Gothenburg, Sweden

Outcomes

Primary Outcomes

Plasma concentrations of key metabolites derived from chlorogenic acid, caffeine, trigonelline and diterpenes.

Difference in the plasma concentrations between the different types of coffee comparing before (baseline) and after single dose intervention.

Time frame: 24 hours

Plasma concentration-time profile over 24 hours (AUC) of key metabolites derived from chlorogenic acid, caffeine, trigonelline and diterpenes.

Difference in plasma AUC between the different types of coffee for each biomarker candidate.

Time frame: 24 hours

Urine concentrations of key metabolites derived from chlorogenic acid, caffeine, trigonelline and diterpenes.

Difference in the urine concentrations between the different types of coffee comparing before (baseline) and after single dose intervention.

Time frame: 24 hours

Plasma kinetic profiles of key metabolites derived from chlorogenic acid, caffeine, trigonelline and diterpenes.

Cmax will be estimated.

Time frame: 24 hours

Plasma kinetic profiles of key metabolites derived from chlorogenic acid, caffeine, trigonelline and diterpenes.

Tmax will be estimated.

Time frame: 24 hours

Secondary Outcomes

Plasma concentrations of key metabolites derived from chlorogenic acid, caffeine, trigonelline and diterpenes.

Difference in the plasma concentrations between the different types of coffee comparing before (baseline) and after single dose and three days intervention.

Time frame: 4 days

Urine concentrations of key metabolites derived from chlorogenic acid, caffeine, trigonelline and diterpenes.

Data from ClinicalTrials.gov

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