The main purpose of this study is to is to look at how much LY3437943 gets into the bloodstream and how long the body takes to get rid of it in healthy male participants. This study will involve a single dose of 14C radiolabeled LY3437943. his means that a radioactive tracer substance, C14, will be incorporated into the study drug to investigate the study drug and its breakdown products and to find out how much of these pass from blood into urine, feces and expired air. The study will last up to approximately 15 weeks including the screening period of 28 days.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
7
Administered SC.
Covance Clinical Research Unit
Madison, Wisconsin, United States
Urinary Excretion of LY3437943 Radioactivity Over Time Expressed as a Percentage of the Total Radioactive Dose Administered
Urinary Excretion of LY3437943 Radioactivity Over Time Expressed as a Percentage of the Total Radioactive Dose Administered
Time frame: Predose up to 63 days post dose
Fecal Excretion of LY3437943 Radioactivity Over Time Expressed as a Percentage of the Total Radioactive Dose Administered
Fecal Excretion of LY3437943 Radioactivity Over Time Expressed as a Percentage of the Total Radioactive Dose Administered
Time frame: Predose up to 63 days post dose
PK: Area Under the Concentration-Time Curve From Time Zero to Infinity (AUC (0-∞)) of Total Radioactivity and [¹⁴C]-LY3437943
PK: AUC (0-∞) of Total Radioactivity and \[¹⁴C\]-LY3437943
Time frame: Predose up to 63 days post dose
PK: Maximum Concentration (Cmax) of Total Radioactivity and [¹⁴C]-LY3437943
PK: Cmax of Total Radioactivity and \[¹⁴C\]-LY3437943
Time frame: Predose up to 63 days post dose
Total Radioactivity Recovered in Urine, Feces, and Expired Air (if applicable)
Total Radioactivity Recovered in Urine, Feces, and Expired Air (if applicable)
Time frame: Predose up to 63 days post dose
Total Number of Metabolites of LY3437943
Total Number of Metabolites of LY3437943
Time frame: Predose up to 63 days post dose
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