Vincristine is a major anticancer agent in the management of hematological malignancies. One of the main side effects is chemotherapy-induced peripheral neuropathy (CIPN). CIPN is a characteristic side effect of neurotoxic anticancer drugs. CIPN associated with vincristine is typically characterized by distal and symmetrical sensory symptoms (dysesthesia and paresthesia). Motor and vegetative symptoms can also be found. The prevalence of CIPN associated with vincristine during treatment ranges from 12 to 100% in children (depending on the endpoint). The aim of this cross-sectionnal study will be to explore the CIPN prevalence and severity in adult survivors of childhood leukemia and having been treated by vincristine.
Adult survivors of chidlhood leukemia and having been treated by vincristine will be contacted from the French childhood cancer survivor study for leukaemia (LEA Cohort) in order to seek their participation agreement. Thereafter patients will received a self-administered questionnaire exploring the chemotherapy-induced peripheral neuropathy and related comorbidities (pain, neuropathic pain, anxiety, depression, health-related quality of life, substance use, physical activity, deprivation). Oncological and sociodemographic characteristics of participants will be recorded.
Study Type
OBSERVATIONAL
Enrollment
467
Patients will answer to a self- administered questionnaire exploring chemotherapy-induced peripheral neuropathy and related comorbidities
CHU Clermont-Ferrand
Clermont-Ferrand, France
Sensitive chemotherapy-induced peripheral neuropathy
Scores of the sensitive subscale of the QLQ-CIPN20 questionnaire (quality of life questionnaire - chemotherapy-induced peripheral neuropathy 20 questions) scores : 0 least - 100 worst
Time frame: day 1
Motor chemotherapy-induced peripheral neuropathy
Scores of the motor subscale of the QLQ-CIPN20 questionnaire (quality of life questionnaire - chemotherapy-induced peripheral neuropathy 20 questions) scores : 0 least - 100 worst
Time frame: day 1
Pain severity
Scores of pain severirty assessed with a visual analogic scale scores : 0 no pain - 10 maximal pain
Time frame: day 1
Neuropathic pain
Scores of the DN4 interview questionnaire (Douleur neuropathique 4 questions) Scores : 0 least - 7 worst Threshold for neuropathic pain : 3
Time frame: day 1
Ongoing analgesic treatment
Reporting of ongoing analgesic treatment declared by the patient
Time frame: day 1
Anxiety severity
Scores of the anxiety subscale of the HADS questionnaire (Hospital anxiety and depression scale) Anxiety scores: 0 least - 21 worst Normal scores: ≤7 Borderline or suggestive of possible anxiety: 8-10 Indicative of anxiety: ≥11
Time frame: day 1
Depression severity
Scores of the depression subscale of the HADS questionnaire (Hospital anxiety and depression scale) Depression scores: 0 least - 21 worst Normal scores: ≤7 Borderline or suggestive of possible depression: 8-10 Indicative of depression: ≥11
Time frame: day 1
Health-related quality of life
Scores of the SF36 questionnaire (short-form 36) for each item: 0 worst - 100 best
Time frame: day 1
Physical activity and sedentarity
GPAQ questionnaire (Global Physical Activity Questionnaire) Work-related physical activity (minutes) Leisure-related physical activity (minutes) Time spent sitting (minutes)
Time frame: day 1
Deprivation
Scores of the EPICES questionnaire (Evaluation de la Précarité et des Inégalités de santé dans les Centres d'Examens de Santé) Scores: 0 best - 100 worst
Time frame: day 1
Use of legal and illegal psychoactive drugs
Reporting of legal psychoactive drug use (alcohol, tobacco, e-cigarette, psychoactive medication, cannabidiol, and other), and illegal psychoactive drug use (cannabis, and other)
Time frame: day 1
Oncological characteristics
Type of hematological malignancy and date of diagnosis ; Chemotherapy received: vincristine (date of last course and cumulative dose), anthracyclines (cumulative dose) ; Radiation therapy received: central nervous system irradiation and total dose, total body irradiation and total dose ; Hematopoietic stem cell (HSC) transplant: autograft or allograft, and date of transplant(s) ; Relapse (date)
Time frame: day 1
Oncological characteristics
Type of hematological malignancy, date of diagnosis, and relapse (date)
Time frame: day 1
Anticancer drugs received
vincristine (date of last course and cumulative dose), and anthracyclines (cumulative dose)
Time frame: day 1
Radiation therapy received
Central nervous system irradiation (total dose), total body irradiation (total dose)
Time frame: day 1
Hematopoietic stem cell transplant
Autograft or allograft, and date of transplant(s)
Time frame: day 1
Sociodemographic characteristics
Age at the time of the response to the study questionnaire ; Age at diagnosis of hematological malignancy ; Gender ; Weight, height, body surface area, weight-for-age and sex-percentile at diagnosis ; Weight, height and BMI at time of response ; Intercurrent pathology at time of response ; socio-professional group
Time frame: day 1
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.