This study was conducted to assess the benefit of locally delivered melatonin gel as adjunctive to scaling and root planning (SRP) in the treatment of chronic periodontitis.
Forty chronic periodontitis selected patients ,divided into two groups. Group I: included 20 chronic periodontitis patients, treated by conventional periodontal therapy SRP combined with intra- pocket application of Melatonin gel once weekly for 1 month begin application at the second week after initial therapy. Group II: included 20 chronic periodontitis patients, treated by SRP combined with the injection of placebo, weekly for one month. The periodontal parameters were recorded at baseline, 1week, 1and 3 months.Gingival crevicular fluid (GCF) samples were collected and a quantitative measurement of receptor activator nuclear K ligand (RANKL) was carried out by using Enzyme-Linked Immunosorbent Assay (ELISA) at baseline, 1week, 1 and 3 months.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
40
Intra-pocket application of 2% Melatonin gel
placebo intra-pocket application
Alazhar university ,faculty of Dental Medicine
Asyut, Egypt
Efficacy of Melatonin gel by determine the change on measurements of clinical parameter in chronic periodontitis.
positive change in clinical parameter by millimeter
Time frame: 2 weeks
EFFICACY of Melatonin Gel by positive change measurements of clinical parameter "pocket depth ,attachment loss"
positive change in clinical parameter by millimeter
Time frame: 1: 3 months
EFFICACY of Melatonin Gel by positive change on concentration level of Receptor activator nuclear K ligand ( RANKL) in Gingival crevicular fluid (GCF)
microbiology analysis by Receptor activator nuclear K ligand(ELISA ) by picogram
Time frame: 3 months
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.