Prevention of Post-Operative Nausea and Vomiting With Propofol Infusion

Milton S. Hershey Medical Center68 enrolled

Overview

The purpose of this study is to clarify whether or not a low-dose propofol infusion can effectively prevent postoperative nausea and vomiting (PONV) in patients who have a documented history of PONV and/or motion sickness.

Propofol is administered as both low dose and as sole anesthetic in patients with history of PONV and/or motion sickness. But efficacy of one dose over the other is not studied. This study plans to clarify if propofol in low dose is as effective as its administration as sole anesthetic in patients with history of PONV and/or motion sickness

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Post-operative Nausea and Vomiting

Interventions

PropofolDRUG

Propofol is administered starting at surgery induction and ending at skin closure

PlaceboOTHER

Placebo is administered starting at surgery induction and ending at skin closure

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Undergoing general anesthesia for elective surgery 2. Documented history of Patient's self-disclosure of PONV and/or motion sickness during pre-anesthesia discussions 3. No documented allergy/adverse reaction to propofol 4. English speaking 5. At least 18 years of age Exclusion Criteria: 1. Any anti-nausea medication taken within 24 hours prior to surgery 2. Unable to provide consent independently 3. Allergy or adverse reaction to propofol 4. Emergency surgery

Locations (1)

Penn State Health Milton S Hershey Medical Center

Hershey, Pennsylvania, United States

Outcomes

Primary Outcomes

Nausea (urge to vomit) episodes

Number of self-reported nausea episodes

Time frame: 24 hours

Retching (labored, spasmodic, rhythmic contractions of respiratory muscles without expulsion of gastric contents) episodes

Number of self-reported retching episodes

Time frame: 24 hours

Vomiting (forceful expulsion of gastric contents) episodes

Number of self-reported vomiting episodes

Time frame: 24 hours

Secondary Outcomes

Choice of antiemetic- Dexamethasone

medication administered.

Time frame: 24 hours

Number of times dexamethasone administered

frequency of administration

Time frame: 24 hours

Choice of antiemetic- Ondansetron

medication administered.

Time frame: 24 hours

Number of times ondansetron administered

frequency of administration

Time frame: 24 hours

Choice of antiemetic- Promethazine

medication administered

Time frame: 24 hours

Number of times promethazine administered

frequency of administration

Data from ClinicalTrials.gov

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