This study focused on the alterations of gut microbiome and function during defunctioning ileostomy, and observed the effects of probiotic intervention on intestinal microbiome and function. The investigators looked forward to find the specific intestinal maladjusted flora from this work, which could provide a new scheme for the subsequent treatment of the damaged intestinal function and the reduction of the incidence of postoperative complication.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
64
4 tablets of MIYAIRI 588 were inserted into the distal ileostomy once a week for 6 months
Huashan hospital
Shanghai, China
RECRUITINGWexner incontinence score
Assess defecation function，the score range is 0-20, 0 is normal, 20 is complete incontinence
Time frame: 1 year
fecal incontinence quality-of-life scale
The Fecal Incontinence Quality of Life Scale is composed of a total of 29 items; these items form four scales: Lifestyle (10 items), Coping/Behavior (9 items), Depression/Self-Perception (7 items), and Embarrassment (3 items). The score of each scale is 1-4 points. The higher the score, the worse the quality of life.
Time frame: 1 year
Rate of postoperative complications
Such as anastomotic leakage, operative death, intestinal obstruction, intestinal infection，etc.
Time frame: 1 month after operation
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