The aim is to evaluate the presence of mild cognitive impairment (MCI) in patients with inflammatory bowel disease (IBD). This will be done by cognitive tests. Along them, screening for depression, anxiety and stress will be done. A blood sample for determining serum values of homocysteine, protein S100-B, amyloid and BDNF will be stored. Patients will be followed-up for 2 years.
The aim is to evaluate the presence of mild cognitive impairment (MCI) in patients with inflammatory bowel disease (IBD). This will be done by cognitive tests. Along them, screening for depression, anxiety and stress will be done. A blood sample for determining serum values of homocysteine, protein S100-B, amyloid and BDNF will be stored. Patients will be followed-up for 2 years. Study has 3 phases: inclusion, 1 year visit and 2 year visit. Inclusion: consent signing, checking exclusion and inclusion criteria, cognitive testing, blood sample storing, questionnaires for screening. 1. year visit: cognitive testing. 2. year visit: cognitive testing.
Study Type
OBSERVATIONAL
Enrollment
75
Cognitive tests will be carried: MOCA, trail making test, digit symbol substitution, forward and backward digit testing.
Oliviu Florențiu Sârb
Cluj-Napoca, Cluj, Romania
RECRUITINGClinica de Hepatologie si Gastroenterologie "Digenio"
Cluj-Napoca, Romania
RECRUITINGSpitalul Clinic CF Cluj-Napoca
Cluj-Napoca, Romania
RECRUITINGMontreal cognitive assessment score (MOCA)
MOCA has 0-30 points
Time frame: inclusion
Trail Making Test A (TMT-A)
Scored from 0-100 seconds
Time frame: inclusion
Trail Making Test B (TMT-B)
Scored from 0-300 seconds
Time frame: inclusion
Digit symbol substitution test
0-90 points
Time frame: inclusion
Forward digit span testing
0-16 points
Time frame: inclusion
Forward digit span testing
0-16 points
Time frame: 1 year
Forward digit span testing
0-16 points
Time frame: 2 years
Backward digit span testing
0-14 points
Time frame: inclusion
Backward digit span testing
0-14 points
Time frame: 1 year
Backward digit span testing
0-14 points
Time frame: 2 years
Serum homocysteine
mg/dl
Time frame: inclusion
Serum brain derived neurotrophic factor (BDNF)
ug/ml
Time frame: inclusion
Serum S100-B protein
ug/ml
Time frame: inclusion
Serum amyloid
ug/ml
Time frame: inclusion
Montreal cognitive assessment score (MOCA)
MOCA has 0-30 points
Time frame: 1 year
Montreal cognitive assessment score (MOCA)
MOCA has 0-30 points
Time frame: 2 years
Depression score
0-42 points
Time frame: inclusion
Quality of life score
0-100 points for each domain 4 domains: * Social relationships * Environment * Physical health * Psychological
Time frame: inclusion
Stress score
0-42 points
Time frame: inclusion
Anxiety score
0-42 points
Time frame: inclusion
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