Pulmonary vein isolation (PVI) is currently the cornerstone non pharmacological therapy for drug-refractory atrial fibrillation (AF). Where rhythm control has been shown to be inferior as compared to rate control in older trials. New data suggest that for patients with heart failure and AF PVI may improve prognosis (mortality) as compared to medical rate or rhythm control. Whether optimal rate control as can be achieved with atrioventricular node ablation is comparable with regard to all-cause mortality of heart failure hospitalization to PVI in patients with heart failure and AF is unknown.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Ablation of either the pulmonary veins or the atrioventricular node
University Medical Center Groningen
Groningen, Netherlands
All-cause death.
Occurence of all-cause death.
Time frame: 1 year
cardiovascular hospitalization.
Occurence of cardiovascular hospitalization (heart failure or stroke).
Time frame: 1 year
Quality of life
Change in quality of life (using the Kansas City Cardiomyopathy Questionnaire (KCCQ)).
Time frame: 1 year
Death from any cause
Occurence of death from any cause.
Time frame: 1 year
Unplanned hospitalization
Occurence of unplanned hospitalization related to heart failure.
Time frame: 1 year
death from cardiovascular disease
Occurence of death from cardiovascular disease.
Time frame: 1 year
cerebrovascular accident.
Occurence of stroke.
Time frame: 1 year
unplanned hospitalization for cardiovascular disease
Any unplanned hospitalization for cardiovascular disease.
Time frame: 1 year
Any hospitaliation
Any hospitalization for non-cardiovascular disease.
Time frame: 1 year
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changes in the Kansas city cardiomyopathy questionnaire
Changes in quality of life (any)
Time frame: 1 year
procedure related adverse events
Occurence of procedure related adverse events.
Time frame: 1 year
atrial fibrillation-free intervals were assessed.
Assessment of AF free intervals.
Time frame: 1 year