Clinical Significance and Coexistence of Polymorphisms of Individual Collagen-coding Genes

Polish Mother Memorial Hospital Research Institute250 enrolled

Overview

The purpose of this study is to assess correlation between recurrent patella dislocation and genetic polymorphism rs1800012 of the COL1A1 Gene and rs12722 of the COL5A1 Gene.

After being informed about the study and potential risk all of participants were performed phisical examination and genetic test. In the study we established two groups: In first group- 50 patients with recurrent patellar dislocation and without any genetic disorders. In the second one 200 patients without recurrent patellar dislocation and genetic disorders. All pediatric patients were between 7 and 17 years old in two groups respectivly.

Study Type

OBSERVATIONAL

Enrollment

250

Conditions

Ligament; Laxity Recurrent Patellar Dislocation

Interventions

genetic testDIAGNOSTIC_TEST

COL1A1 or COL5A1 genetic test

Beighton joint laxity testOTHER

Based on Beighton scale.

Eligibility

Sex: ALLMin age: 7 YearsMax age: 17 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: • First-time diagnosed or recurrent patellar dislocation patient from 7 to 17 age years old. Exclusion Criteria: * Patient's age under 7. * Presence of genetic diseases such as: Down's syndrome or Marfan's syndrome. * Metabolic disorders. * Previous knee surgeries. * Cartilage and bone fractures in the knee. * No consent for examination from the legal guardian.

Locations (2)

Krzysztof Małecki

Lodz, Lodzkie Voivodeship, Poland

Krzysztof Małecki

Lodz, Lodzkie Voivodeship, Poland

Outcomes

Primary Outcomes

Patients with recurrent patellar dislocation

Time frame: 2022-2023

Control group without obvious joint hipermobility

Time frame: 2022-2023

Data from ClinicalTrials.gov

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