This study follows an open-label, single arm design with two periods with rosuvastatin, digoxin and ABBV-CLS-7262
Period 1: One single dose of rosuvastatin and one single dose of digoxin on Day 1. Period 2: Multiple doses of ABBV-CLS-7262 once daily from Day 1 to Day 8. On Day 5, one single dose of rosuvastatin and one single dose of digoxin with the dose of ABBV-CLS-7262 on that day.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
12
Drug: ABBV-CLS-7262 Drug: Digoxin Drug: Rosuvastatin
AbbVie Clinical Pharmacology Research Unit (ACPRU)
Grayslake, Illinois, United States
Pharmacokinetics of Rosuvastatin
Area under the Curve (AUC)
Time frame: Two Weeks
Pharmacokinetics of Digoxin
Area under the Curve (AUC)
Time frame: Two Weeks
Safety and Tolerability
Number of patients with treatment-related adverse events as assessed by CTCAE v4.03
Time frame: Two Weeks
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.