The primary objective of the study is to test the impact of positive and negative body pressure on exercise capacity, symptoms, blood volume distribution and central cardiac hemodynamics in patients with heart failure and preserved ejection fraction. Aim 1 will study healthy volunteers and heart failure patients non invasively while Aim 2 will study heart failure patients invasively (intracardiac pressures).
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
27
Positive or negative pressure is applied via a closed chamber.
Duke University Medical Center
Durham, North Carolina, United States
change in exercise cardiac output
Change in cardiac output from rest to 0 Watts exercise
Time frame: Day 1
change in exercise cardiac output
Change in cardiac output from rest to 20 Watts exercise
Time frame: Day 1
change in heart rate
Change in heart rate from rest to 0 Watts exercise
Time frame: Day 1
change in heart rate
Change in heart rate from rest to 20 Watts exercise
Time frame: Day 1
change in respiratory rate
Change in heart rate from rest to 20 Watts exercise
Time frame: Day 1
change in O2 consumption
Change in O2 consumption from rest to 0 Watts exercise
Time frame: Day 1
change in O2 consumption
Change in O2 consumption from rest to 20 Watts exercise
Time frame: Day 1
Change in wedge pressure
Change in wedge pressure from rest to 0 Watts exercise
Time frame: Day 1
Change in wedge pressure
Change in wedge pressure from rest to 20 Watts exercise
Time frame: Day 1
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