The primary objective of the study is to test the impact of positive and negative body pressure on exercise capacity, symptoms, blood volume distribution and central cardiac hemodynamics in patients with heart failure and preserved ejection fraction. Aim 1 will study healthy volunteers and heart failure patients non invasively while Aim 2 will study heart failure patients invasively (intracardiac pressures).
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
27
Positive or negative pressure is applied via a closed chamber.
Duke University Medical Center
Durham, North Carolina, United States
Change in Oxygen (O2) Consumption From Rest to 20 Watts Exercise
A positive value indicates greater O2 consumption.
Time frame: Day 1
Change in Cardiac Output From Rest to 0 Watts Exercise
Time frame: Day 1
Change in Cardiac Output From Rest to 20 Watts Exercise
Time frame: Day 1
Change in Heart Rate From Rest to 0 Watts Exercise
A positive value indicates and increase in heart rate.
Time frame: Day 1
Change in Heart Rate From Rest to 20 Watts Exercise
A positive value indicates an increase in heart rate.
Time frame: Day 1
Change in Respiration From Rest to 20 Watts Exercise
A positive value indicates an increase in respiration.
Time frame: Day 1
Change in O2 Consumption From Rest to 0 Watts Exercise
A positive value indicates an increase in oxygen consumption.
Time frame: Day 1
Change in O2 Consumption From Rest to 20 Watts
A positive value indicates an increase in oxygen consumption.
Time frame: Day 1
Change in Wedge Pressure From Rest to 20 Watts
Time frame: Day 1
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Change in Symptom Burden From Rest to 20 Watts
Time frame: Day 1