Effectiveness of Yunnan Baiyao in Improving Fracture Pain

Inclusion Criteria: 1. The age of the subject is 20-70 years old; 2. Patients with distal radius fractures (Colles fractures) ; 3. Conservative treatment (closed reduction and fixation) after fracture; 4. Willingness to participate in this study and sign the informed consent form (ICF). Exclusion Criteria: 1. Pathological fractures such as multiple fractures and cancer; 2. Patients with a history of severe chronic disease, such as hypertension, coronary heart disease, diabetes, tuberculosis, etc.; 3. Patients with endocrine diseases unsuitable for inclusion or other related diseases affecting bone metabolism, such as thyroid diseases of clinical significance as hyperparathyroidism, parathyrometaplasia, Paget's disease, Cushing's syndrome, nephrotic rickets, osteomalacia, rheumatoid arthritis, gout, multiple myeloma, osteogenesis insufficiency, etc.; 4. Complicated with malignant tumor, mental illness and other diseases that doctors think may affect the test process; 5. Currently using bone metabolism regulation drugs, such as teripartide, bisphosphonate, etc.; 6. Had a history of chronic pain and used painkillers daily before enrollment; Nonsteroidal anti-inflammatory drugs, opioids, and physical therapy for pain relief within a week after fracture; 7. pregnant and lactating women; 8. Allergic to Yunnan Baiyao or any excipients and celecoxib, or suffering from contraindications or intolerance indicated by the test drug; 9. continuous use of antibiotics; 10. Patients with coagulation dysfunction, receiving anticoagulant therapy or taking antiplatelet aggregation drugs.