This study evaluates whether clinical evaluation tools such as the six-minute walk test, hand grip strength test, and gait speed test, are useful in predicting risk of complications in patients undergoing hematopoietic stem cell transplants (HCT). Being able to predict who is at increased risk of post-HCT complications can help better inform patients and providers on the risks and benefits of undergoing HCT and determine whether certain patients should have closer post-HCT monitoring due to an increased risk of complications.
PRIMARY OBJECTIVE: I. To develop novel pre-transplant tools for determining risk of post-HCT pulmonary complications. OUTLINE: This is an observational study. Patients undergo a clinical evaluation consisting of a six-minute walk test, hand grip strength test, and gait speed test on study. Patients' medical records are also reviewed for a year on study.
Study Type
OBSERVATIONAL
Enrollment
137
Undergo clinical evaluation
Medical records reviewed
Mayo Clinic in Rochester
Rochester, Minnesota, United States
Pulmonary complication following hematopoietic stem cell transplant (HCT)
Pulmonary complications may include but are not limited to: infection, HCT-specific lung injury syndromes, acute respiratory distress syndrome, pulmonary graft versus host disease. Univariable analysis will be first used to identify potential factors that predict post-HCT pulmonary complications. All possible factors will then be included in multivariable analysis. Will also specifically test whether the six-minute walk test, grip strength and gait speed add additional significance to pulmonary complications and the statistic model after including pulmonary function test results.
Time frame: Up to 1 year after transplant
100-day mortality
Analyses similar to those for the primary outcome will be conducted.
Time frame: At 100 days after transplant
1 year mortality
Analyses similar to those for the primary outcome will be conducted.
Time frame: At 1 year after transplant
Relapse-free survival
Analyses similar to those for the primary outcome will be conducted.
Time frame: At 1 year after transplant
Hospital or intensive care unit admission post-HCT
Will specifically test whether the six-minute walk test, grip strength and gait speed add additional significance to pulmonary complications and the statistic model after including pulmonary function test results.
Time frame: Up to 1 year after transplant
Need for noninvasive or invasive mechanical ventilation
Will specifically test whether the six-minute walk test, grip strength and gait speed add additional significance to pulmonary complications and the statistic model after including pulmonary function test results.
Time frame: Up to 1 year after transplant
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