Hyperpolarized 129Xe MRI Lung Health Cohort

University of Kansas Medical Center260 enrolled

Overview

A subset of young adults participating in the American Lung Association (ALA) Lung Health Cohort (LHC) will be imaged using Hyperpolarized 129Xe MRI to assess lung structure and function. Images will be used to improve the understanding of lung health and early lung abnormalities that may lead to chronic lung disease.

Study Type

OBSERVATIONAL

Enrollment

260

Conditions

Healthy

Interventions

Hyperpolarized Xe129DRUG

Inhaled hyperpolarized 129Xe used as a signal agent for MRI of the lungs.

Eligibility

Sex: ALLMin age: 25 YearsMax age: 35 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Is enrolled in the American Lung Association Lung Health Cohort Study. * Has completed CT imaging for the LHC study within 2 years of the scheduled Xe-MRI date. Exclusion Criteria: * Pacemaker, internal defibrillator or other implanted electronic devices or any standard MRI contraindications (e.g., claustrophobia, \> 140 cm shoulder circumference, dependent on weight distribution). * Is pregnant or breastfeeding * Oxygen saturation (SpO2) \<88% on room air or with supplemental oxygen.

Locations (6)

University of Illinois-Chicago

Chicago, Illinois, United States

NOT_YET_RECRUITING

University of Iowa

Iowa City, Iowa, United States

RECRUITING

University of Kansas Medical Center

Kansas City, Kansas, United States

Outcomes

Primary Outcomes

Xe-MRI Apparent Diffusion Coefficient

Correlation of Xe-MRI with FEV1/FVC and other measures of lung function

Time frame: At baseline imaging timepoint

Central Contacts

Cristal Monge

CONTACT

913-945-9399 chernandez@kumc.edu

Data from ClinicalTrials.gov

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