Genetic Markers and Biomarkers in Patients With Intellectual Disabilities of Genetic Origin

Institut Jerome Lejeune2,000 enrolled

Overview

Analyze genetic and biological markers in patients with Intellectual Deficiencies (ID) of genetic origin in order to better understand the mechanisms of modified genes, cellular mechanisms, pathways involved in different disorders , complications and pathologies associated with ID of genetic origin.

Blood and skin samples will be taken from patients coming at the outpatients clinic of the Institut Jérôme Lejeune and who consent to participate to the study. Search and identification of markers will be then done from the collected samples.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

2,000

Conditions

Down Syndrome Intellectual Disability

Interventions

Biological samplingsOTHER

Blood and/or skin samples

Eligibility

Sex: ALLHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patient diagnosed with an intellectual disability of genetic origin * Patient of all ages coming for consultation at the Institut Jérôme Lejeune * Patient whose parents or legal representative have received and understood the information document and signed the informed consent for a sample for the research project. * Patient affiliated to a social security scheme Exclusion Criteria: * Parents unable to find out about the constraints related to the study * Refusal of informed patient participation * Pregnant, parturient and nursing mothers * Persons deprived of their liberty by judicial or administrative decision

Locations (1)

Institut Jérôme Lejeune

Paris, France

RECRUITING

Outcomes

Primary Outcomes

Identification of biomarkers in blood

Analysis of biomarkers from blood samples taken during the visit

Time frame: 10 years

Identification of biomarkers from skin samples

Analysis of biomarkers from skin samples taken during the visit

Time frame: 10 years

Central Contacts

Sophie Durand

CONTACT

+33156586300 sophie.durand@institutlejeune.org

Data from ClinicalTrials.gov

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