Synovial and Adipose Tissue Composition in Overweight/Obese Patients With Active Rheumatoid Arthritis Under JAK/STAT Inhibition

Inclusion Criteria: * Patients fulfilling 2010 ACR/EULAR classification criteria for Rheumatoid Arthritis. * Patients with inadequate response to Methotrexate at the maximum tolerated dose (10-25 mg/week), or first bDMARD with at least moderate disease activity (DAS28\>3.2), with disease duration \<12 months or naïve to prior biologic therapy. * Patients eligible to Tofacitinib according to the treating physician judgement. * Stable low doses of prednisone (\<5 mg/daily) since at least three months if necessary are allowed at the time of enrollment. Exclusion Criteria: * Severe and uncontrolled infections such as sepsis and opportunistic infections. * Patients who are currently included in any interventional clinical trial in RA. * RA patients treated with more than one biologics. * Subjects who are impaired, incapacitated, or incapable of completing study-related assessments * Subjects with active vasculitis of a major organ system, with the exception of rheumatoid nodules. * Subjects with current symptoms of severe, progressive, or uncontrolled renal, hepatic, hematologic, gastrointestinal, pulmonary, cardiac, neurologic, or cerebral disease, whether or not related to RA and which, in the opinion of the investigator, might place a subject at unacceptable risk for participation in the study. * Female subjects who have had a breast cancer screening that is suspicious for malignancy and in whom the possibility of malignancy cannot be reasonably excluded by additional clinical, laboratory, or other diagnostic evaluations. * Subjects with a history of cancer in the last 5 years, other than non-melanoma skin cell cancers cured by local resection or carcinoma in situ. Existing non-melanoma skin cell cancers should be removed, the lesion site healed, and residual cancer ruled out before administration of the study drug. * Subjects who currently abuse drugs or alcohol. * Subjects with evidence (as assessed by the investigator) of active or latent bacterial or viral infections at the time of potential enrollment, including subjects with evidence of human immunodeficiency virus (HIV) detected during screening. * Subjects with herpes zoster or cytomegalovirus (CMV) that resolved less than 2 months before the informed consent document was signed. * Subjects who have received any live vaccines within 3 months of the anticipated first dose of study medication. * Subjects with any serious bacterial infection within the last 3 months, unless treated and resolved with antibiotics, or any chronic bacterial infection (eg, chronic pyelonephritis, osteomyelitis, or bronchiectasis). * Subjects at risk for tuberculosis (TB). Specifically excluded from this study will be subjects with a history of active TB within the last 3 years, even if it was treated; a history of active TB greater than 3 years ago, unless there is documentation that the prior anti-TB treatment was appropriate in duration and type; current clinical, radiographic, or laboratory evidence of active TB; and latent TB that was not successfully treated (≥ 4 weeks).