Assessing an Oral EGFR Inhibitor,YK-209A in Patients Who Have Advanced Non-small Cell Lung Cancer With EGFR

Inclusion Criteria: General Inclusion Criteria all cohorts: dose escalation, dose expansion, and dose extension: 1. Have histologically or cytologically confirmed locally advanced or metastatic NSCLC disease (Stage IIIB or IV) . 2. Male or femal adult，be able to provide a signed and dated, written informed consent. 3. Must have measurable disease by response evaluation criteria in solid tumors (RECIST) v1.1. 4. Minimum life expectancy of 3 months or more. 5. Adequate organ function at baseline. 6. Normal QT interval on screening electrocardiogram (ECG), defined as QT interval corrected (Fridericia) (QTcF) of less than or equal to (≤ ) 450 millisecond (ms) in males or ≤ 470 ms in females. Part 1: Dose Escalation Cohort Specific Inclusion Criteria: 1. Refractory to standard available therapies. 2. Eastern Cooperative Oncology Group (ECOG) performance status 0 to 1. 3. aged 18-65 years old. 4. previously treated NSCLC patients with EGFR T790M. Part 2: Expansion Cohort 1、2、3 Specific Inclusion Criteria: 1. previously treated NSCLC patients with EGFR T790M. 2. Eastern Cooperative Oncology Group (ECOG) performance status 0 to 2. 3. aged 18-75 years old. Part 2: Expansion Cohort 4、5 Specific Inclusion Criteria: 1. previously treated NSCLC patients with EGFR exton 20ins. 2. Eastern Cooperative Oncology Group (ECOG) performance status 0 to 2. 3. aged 18-75 years old. Part 3: Expansion Cohort 6 Specific Inclusion Criteria: 1. previously untreated NSCLC patients with EGFR exton 20ins. 2. Eastern Cooperative Oncology Group (ECOG) performance status 0 to 2. 3. aged 18-75 years old. Part 3: Expansion Cohort 7、8 Specific Inclusion Criteria: 1. previously treated NSCLC patients with EGFR rare mutation(（G719X、L861Q、S768I). 2. Eastern Cooperative Oncology Group (ECOG) performance status 0 to 2. 3. aged 18-75 years old. Part 3: Expansion Cohort9 Specific Inclusion Criteria: 1. previously treated NSCLC patients with EGFR exton 20ins. 2. Eastern Cooperative Oncology Group (ECOG) performance status 0 to 2. 3. aged 18-75 years old. Exclusion Criteria: 1. Any cytotoxic chemotherapy, investigational agents or other anticancer drugs from a previous treatment regimen or clinical study within 14 days before screening. 2. Radiotherapy with a limited field of radiation for palliation within 1 week of the first dose or with a wide field of radiation which must be completed within 4 weeks before screening. 3. NSCLC patients with EGFR T790M mutation previously treated with third-generation EGFR-TKIs (such as AZD9291, CO-1686, HM61713, EGF816, PF-06747775, vometinib, BPI-15086, Ivirtinib maleate, etc.) and their apis or the same drugs in other clinical trials Drug treatment. 4. Patients with NSCLC with EGFR ex20ins mutation had previously received EGFR ex20ins inhibitors and/or EGFR-cMET double antibodies (including but not limited to TAK-788, bociotinib, JNJ-61186372, DZD9008, vometinib, PLB1004, and AZD9291 in excess of the clinically approved dose (cohort 9 prohibited AZD9291 at any dose) and Drug substance or other similar drug treatment in the clinical trial stage. 5. NSCLC patients with rare EGFR mutations have previously been treated with third-generation EGFR-Tkis (such as AZD9291, etc.) and their apis or other similar drugs in clinical trials. 6. Received a moderate or strong CYP4503A inhibitor or moderate or strong CYP3A inducer within 10 days prior to first dose of YK-029A. 7. Have significant, uncontrolled, or active cardiovascular disease. 8. Have a known history of uncontrolled hypertension. Participants with hypertension should be under treatment on study entry to control blood pressure. 9. Have prolonged QTcF interval, or being treated with medications known to be associated with the development of torsades de pointes. 10. Have an ongoing or active infection, including but not limited to, the requirement for intravenous (IV) antibiotics, or a known history of human immunodeficiency virus, hepatitis B virus (HBV), or hepatitis C virus (HCV). Testing is not required in the absence of history. 11. Currently have or have a history of interstitial lung disease, radiation pneumonitis that required steroid treatment, or drug-related pneumonitis. 12. Female participants who are lactating and breastfeeding or have a positive urine or serum pregnancy test during the screening period. Note: Female participants who are lactating will be eligible if they discontinue breastfeeding. 13. Have gastrointestinal illness or disorder that could affect oral absorption of YK-029A. 14. Have any condition or illness that, in the opinion of the investigator, might compromise participant safety or interfere with the evaluation of the safety of the drug. 15. Judgment by the investigator that the patient should not participate in the study if the patient is unlikely to comply with study procedures, restrictions and requirements.