Cardiovascular performance and overall fitness can be improved by high-intensity aerobic activity, and these benefits may be achievable by persons with rheumatic diseases. The investigators hypothesize that a 12-week high-intensity interval exercise program will provide substantial improvements in cardiovascular function, inflammation and symptoms affecting quality of life.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
87
Twelve weeks of supervised high intensity aerobic and resistance exercise including two sessions/week, one additional session of the patient´s own choice, non-supervised. The target of the high intensity intervals (HIIT) is 90%-95% of maximum heart rate alternated with recovery phases at 70% of maximal heart rate. The resistance exercise session of large muscle groups: 8-10 repetitions, 2-3 sets. Exercise guidance follows principles of self-efficacy and person-centeredness.
Sahlgrenska university hospital
Gothenburg, Sweden
Uddevalla Hospital
Uddevalla, Sweden
Cardiopulmonary function
Maximum oxygen uptake (VO2ml/min/kg) (Higher value indicate better cardiorespiratory capacity)
Time frame: 0 -12 weeks
Vascular function
Aortic pulse wave velocity (PWV) (m/sec.) (Higher PWV value indicate worse vascular function)
Time frame: 0-12 weeks
Level of disease activity
Disease activity score 28 (DAS28) (Range 0-10 where a higher score indicate worse disease activity)
Time frame: 0-12 weeks
Level of disease activity
Disease activity score 28 (DAS28) (Range 0-10 where a higher score indicate worse disease activity)
Time frame: 0-6 months
Level of disease activity
Disease activity score 28 (DAS28) (Range 0-10 where a higher score indicate worse disease activity)
Time frame: 0-12 months
Homeostatic model assessment of insulin resistance (HOMA IR)
Measure of insulin resistance (fasting glucose (mmol/L) and fasting insulin (mIU/ L) will be combined to report HOMA IR
Time frame: 0-12 weeks
Glycosylation level of hemoglobin (HbA1c)
Glycosylation level of hemoglobin (mmol/mol)
Time frame: 0-12 weeks
Level of blood lipids
Levels of triglycerides (mmol/L), Level of high-density lipoprotein (HDL) (mmol/L), low-density lipoprotein (LDL) ( mmol/L), Total cholesterol (mmol/L )
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Time frame: 0-12 weeks
Erythrocyte Sedimentation Rate (ESR)
Level of high sensitivity ESR (mm/h) (Higher score indicate higher inflammation)
Time frame: 0-12 weeks
Erythrocyte Sedimentation Rate (ESR)
Level of high sensitivity ESR (mm/h) (Higher score indicate higher inflammation)
Time frame: 0-6 months
Erythrocyte Sedimentation Rate (ESR)
Level of high sensitivity ESR (mm/h) (Higher score indicate higher inflammation)
Time frame: 0-12 months
C-Reactive Protein (CRP)
Level of high sensitivity CRP (mg/L) (Higher score indicate higher inflammation)
Time frame: 0-12 weeks
C-Reactive Protein (CRP)
Level of high sensitivity CRP (mg/L) (Higher score indicate higher inflammation)
Time frame: 0-6 months
C-Reactive Protein (CRP)
Level of high sensitivity CRP (mg/L) (Higher score indicate higher inflammation)
Time frame: 0-12 months
Cytokine levels
Interleukin-6 (pg/mL), interleukin-10 (pg/mL), tumour necrosis factor-alpha (pg/mL)
Time frame: 0-12 weeks
Muscle function of lower extremities
The one minute sit-to-stand test (Higher numbers of complete rises indicate better muscle function in lower extremities)
Time frame: 0-12 weeks
Hand-grip force
Hand-grip force is assessed with a dynamometer ( Higher value indicate better grip strength)
Time frame: 0-12 weeks
Self-reported physical activity
Self-reported questionnaire of habitual physical activity during a typical week. Numbers of hours on low, moderate and high intensity is summed for each category (A minimum of 150 minutes on moderate intensity or 75 minutes on high intensity are equal to health enhancing physical activity according to World Health Organization guidelines)
Time frame: 0-12 weeks
Self-reported physical activity
Self-reported questionnaire of habitual physical activity during a typical week. Numbers of hours on low, moderate and high intensity is summed for each category (A minimum of 150 minutes on moderate intensity or 75 minutes on high intensity are equal to health enhancing physical activity according to World Health Organization guidelines)
Time frame: 0-6 months
Self-reported physical activity
Self-reported questionnaire of habitual physical activity during a typical week. Numbers of hours on low, moderate and high intensity is summed for each category (A minimum of 150 minutes on moderate intensity or 75 minutes on high intensity are equal to health enhancing physical activity according to World Health Organization guidelines)
Time frame: 0-12 months
Objective assessment of physical activity
Accelerometer to assess habitual physical activity during a typical week. Total time of physical activity and physical activity pattern assessed as time spent at different physical activity intensity levels are obtained using the metabolic equivalent of task values (METS). (Higher METs value indicate higher physical activity level.)
Time frame: 0-12 weeks
Objective assessment of physical activity
Accelerometer to assess habitual physical activity during a typical week. Total time of physical activity and physical activity pattern assessed as time spent at different physical activity intensity levels are obtained using the metabolic equivalent of task values (METS). (Higher METs value indicate higher physical activity level.)
Time frame: 0-6 months
Objective assessment of physical activity
Accelerometer to assess habitual physical activity during a typical week. Total time of physical activity and physical activity pattern assessed as time spent at different physical activity intensity levels are obtained using the metabolic equivalent of task values (METS). (Higher METs value indicate higher physical activity level.)
Time frame: 0-12 months
Pain intensity
Visual Analogue Scale (VAS) (0-100, Higher score indicate worse pain)
Time frame: 0-12 weeks
Pain intensity
Visual Analogue Scale (VAS) (0-100, Higher score indicate worse pain)
Time frame: 0-6 months
Pain intensity
Visual Analogue Scale (VAS) (0-100, Higher score indicate worse pain)
Time frame: 0-12 months
Global health
Visual Analogue Scale (VAS) (0-100, Higher score indicate worse health)
Time frame: 0-12 weeks
Global health
Visual Analogue Scale (VAS) (0-100, Higher score indicate worse health)
Time frame: 0-6 months
Global health
Visual Analogue Scale (VAS) (0-100, Higher score indicate worse health)
Time frame: 0-12 months
Fatigue
The Multiple Fatigue Inventory (MFI-20) (4-20 for each subscale, Higher score indicates a higher degree of fatigue
Time frame: 0-12 weeks
Fatigue
The Multiple Fatigue Inventory (MFI-20) (4-20 for each subscale, Higher score indicates a higher degree of fatigue
Time frame: 0-6 months
Fatigue
The Multiple Fatigue Inventory (MFI-20) (4-20 for each subscale, Higher score indicates a higher degree of fatigue
Time frame: 0-12 months
Sleep
Pittsburgh Sleep Quality Index (0-21, Higher score indicate worse sleep quality).
Time frame: 0-12 weeks
Sleep
Pittsburgh Sleep Quality Index (0-21, Higher score indicate worse sleep quality).
Time frame: 0-6 months
Sleep
Pittsburgh Sleep Quality Index (0-21, Higher score indicate worse sleep quality).
Time frame: 0-12 months
Activity limitations
Health Assessment Questionnaire (HAQ) (0-3, Higher score indicate worse activity limitations)
Time frame: 0-12 weeks
Activity limitations
Health Assessment Questionnaire (HAQ) (0-3, Higher score indicate worse activity limitations)
Time frame: 0-6 months
Activity limitations
Health Assessment Questionnaire (HAQ) (0-3, Higher score indicate worse activity limitations)
Time frame: 0-12 months
Attitude to exercise
Exercise Health Beliefs questionnaire (20-100, Higher score represents stronger exercise health beliefs.
Time frame: 0-12 weeks
Attitude to exercise
Exercise Health Beliefs questionnaire (20-100, Higher score represents stronger exercise health beliefs.
Time frame: 0-6 moths
Attitude to exercise
Exercise Health Beliefs questionnaire (20-100, Higher score represents stronger exercise health beliefs.
Time frame: 0-12 months
Body compositions
Weight and height will be combined to report Body mass index BMI kg/m2 (A higher score indicate higher relative weight)
Time frame: 0-12 weeks
Waist circumference
Measured with a tape measure midway between the lower rib and iliac crest. (A waist measurement of 80 centimeters or more for women and 94 centimeters or more for men indicate increased risk for diseases related to overweight)
Time frame: 0-12 weeks