This study wil examine the effect of altered intrathoracic pressure on lymphatic function, by investigating the lymphatic vessels in the lower limb during mechanical ventilation. The lymphatic function will be examined using Near-Infrared Fluorescence Imaging.
This study wil examine the effect of altered intrathoracic pressure on lymphatic function. This will be done by investigating peripheral lymphatic vessels on patients undergoing surgery for malformations of the jaw who are being mechanically ventilated. Subjects will be examined on two occasions. One to establish baseline function, and one during surgery following a ventilation protocol with altered PIP and PEEP.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
20
Elevated pressure ventilation is defined as a raise in PIP and PEEP by 10 cmH2O from each patients original pressure setting, although never higher than a PIP of 30 cmH2O.
Copenhagen University Hospital
Copenhagen, Denmark
RECRUITINGPeripheral lymphatic velocity (centimeters/second)
Peripheral lymphatic fluid velocity (centimeters/second) will be calculated based upon NIRF sequences.
Time frame: 3 hours
Peripheral lymphatic frequency (contractions/minute)
Peripheral lymphatic contraction frequency (contractions/minute) will be calculated based upon NIRF sequences.
Time frame: 3 hours
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