COMPARISON OF DEXMEDETOMIDINE AND REMIFENTANIL FOR POSTOPERATIVE PAIN IN TRANSPHENOIDAL Pituitary SURGERY

Kocaeli University104 enrolled

Overview

In patients with pituitary adenoma scheduled for endoscopic transsphenoidal pituitary surgery, it was aimed to compare the efficacy of postoperative pain relief of a selective α-2 agonist "Dexmedetomidine" and the rapid and short-acting opioid "Remifentanil" using the "Numerical Rating Scale" (NRS) administered alongside propofol in perioperative maintenance anesthesia. .

Study Type

OBSERVATIONAL

Enrollment

104

Conditions

Postoperative Pain

Interventions

DexmedetomidineDRUG

Efficacy of dexmedetomidine on postoperative pain in patients undergoing transsphenoidal pituitary surgery

RemifentanylDRUG

Efficacy of remifentanyl on postoperative pain in patients undergoing transsphenoidal pituitary surgery

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 18-65 years old * ASA-1 and ASA-2 patients Exclusion Criteria: * Patients in need of postoperative intensive care

Locations (1)

University of Kocaeli

Kocaeli, IZMIT, Turkey (Türkiye)

Outcomes

Primary Outcomes

postoperative pain scale

Comparison of postoperative Numerical Rating Scale(NRS) values of both study arms(min 0, max 10; 10 is unbearable pain )

Time frame: at post anesthesia care unit (T1)

postoperative pain scale

Comparison of postoperative Numerical Rating Scale(NRS) values of both study arms(min 0, max 10; 10 is unbearable pain )

Time frame: 2 hours after surgery (T2)

postoperative pain scale

Comparison of postoperative Numerical Rating Scale(NRS) values of both study arms(min 0, max 10; 10 is unbearable pain )

Time frame: 8 hours after surgery (T3)

postoperative pain scale

Comparison of postoperative Numerical Rating Scale(NRS) values of both study arms(min 0, max 10; 10 is unbearable pain )

Time frame: 24 hours after surgery (T4)

Secondary Outcomes

need for analgesics

Comparison of whether there is a need for additional POSTOPERATIVE analgesic medication

Time frame: Additional analgesic drug requirements at post anesthesia care unit (T1)

need for analgesics

Comparison of whether there is a need for additional POSTOPERATIVE analgesic medication

Time frame: Additional analgesic drug requirements at 2 hours after surgery (T2)

need for analgesics

Comparison of whether there is a need for additional POSTOPERATIVE analgesic medication

Time frame: Additional analgesic drug requirements at 8 hours after surgery (T3)

Data from ClinicalTrials.gov

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