The goal of this prospective, randomized study is to compare recovery characteristics between remimazolam anesthesia with flumazenil and desflurane anesthesia in patients undergoing closed reduction of nasal bone fracture. The main question this study aims to answer is: * Is there statistically significant difference in time from discontinuation of the anesthetic agent up to patient's response to verbal command between these two groups? Participants will receive either remimazolam or desflurane for the maintenance of general anesthesia. When the surgery ends, the anesthetic agent will be stopped. For Remimazolam group, flumazenil will be administered as an antagonist of remimazolam.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
58
General anesthesia was induced with 12 mg/kg/hr of intravenous remimazolam. When loss of consciousness was achieved, the infusion rate of remimazolam was reduced to 1mg/kg/hr for maintenance. At the end of surgery, 0.2 mg of flumazenil is administered.
Desflurane (1 minimum alveolar concentration (MAC) of end-tidal desflurane concentration) is used for the maintenance of general anesthesia. Induction of general anesthesia is achieved with 1-2 mg/kg of intravenous propofol bolus.
Daegu Catholic University Medical Center
Daegu, South Korea
RECRUITINGTime to follow verbal command
Time between discontinuation of anesthetic agent and response to a verbal command of moving participant's foot
Time frame: from discontinuation of anesthetic agent to response to a verbal command of moving participant's foot, up to 30 minutes
time to eye opening
Time between discontinuation of anesthetic agent and eye opening
Time frame: from discontinuation of anesthetic agent to eye opening, up to 30 minutes
time to extubation
Time between discontinuation of anesthetic agent and extubation
Time frame: form discontinuation of anesthetic agent to extubation, up to 30 minutes
Incidence of agitation during emergence period
Ricker Sedation-Agitation Scale (RSAS) \>4
Time frame: from discontinuation of anesthetic agent to 2 minutes after extubation
Mean arterial blood pressure
Mean arterial blood pressure measured in the operating room
Time frame: from 5 minutes before anesthesia induction to end of anesthesia
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